{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Benito-Bueno A"],"funding":["MINECO","CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS","INSTITUTO DE SALUD CARLOS III CIBERCV","FEDER JUNTA DE ANDALUCIA","MCIN/AEI"],"pagination":["9170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9409462"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(16)"],"pubmed_abstract":["The transient outward potassium current (<i>I</i><sub>tof</sub>) is generated by the activation of K<sub>V</sub>4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by K<sub>V</sub>4.3/KChIP2, K<sub>V</sub>4.3/KChIP2/DPP6 and K<sub>V</sub>4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected with cDNAs codifying for different proteins (K<sub>V</sub>4.3/KChIP2, K<sub>V</sub>4.3/KChIP2/DPP6 or K<sub>V</sub>4.3/KChIP2/KCNE2), and the potassium currents were recorded using the whole-cell patch-clamp technique. IQM-266 decreas"],"journal":["International journal of molecular sciences"],"pubmed_title":["Modulation of K<sub>V</sub>4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2."],"pmcid":["PMC9409462"],"funding_grant_id":["FPU17/02731","PID2019-104366RB-C21","PIE202180E073","PRE2018-083280","RYC2018-023837-I","CB/11/00222","PIE201820E104","2019AEP148","BES-2010-036573","A-FQM-386-UGR20","BIO2017-89523-R","BES-2017-080184","SAF2016-75021-R","PID2020-114256RB-I00","RTI2018-097189-B-C22","PID2019-104366RB-C22","PID2020-119805RB-I00"],"pubmed_authors":["Marin-Olivero I","Daniel-Mozo M","Socuellamos PG","Valenzuela C","Gutierrez-Rodriguez M","Martin-Martinez M","Gonzalez-Vera JA","Merinero YG","Cercos P","Perez-Lara A","de Benito-Bueno A","Albert A","Izquierdo C","Orte A"],"additional_accession":[]},"is_claimable":false,"name":"Modulation of K<sub>V</sub>4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2.","description":"The transient outward potassium current (<i>I</i><sub>tof</sub>) is generated by the activation of K<sub>V</sub>4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by K<sub>V</sub>4.3/KChIP2, K<sub>V</sub>4.3/KChIP2/DPP6 and K<sub>V</sub>4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected with cDNAs codifying for different proteins (K<sub>V</sub>4.3/KChIP2, K<sub>V</sub>4.3/KChIP2/DPP6 or K<sub>V</sub>4.3/KChIP2/KCNE2), and the potassium currents were recorded using the whole-cell patch-clamp technique. IQM-266 decreas","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-09T03:16:23.058Z","creation":"2024-10-16T04:12:54.873Z"},"accession":"S-EPMC9409462","cross_references":{"pubmed":["36012438"],"doi":["10.3390/ijms23169170"]}}