biostudies-literaturede Benito-Bueno AMINECOCONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASINSTITUTO DE SALUD CARLOS III CIBERCVFEDER JUNTA DE ANDALUCIAMCIN/AEI9170https://www.ebi.ac.uk/biostudies/studies/S-EPMC9409462biostudies-literatureUnknown23(16)The transient outward potassium current (<i>I</i>_tof) is generated by the activation of K_V4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by K_V4.3/KChIP2, K_V4.3/KChIP2/DPP6 and K_V4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected with cDNAs codifying for different proteins (K_V4.3/KChIP2, K_V4.3/KChIP2/DPP6 or K_V4.3/KChIP2/KCNE2), and the potassium currents were recorded using the whole-cell patch-clamp technique. IQM-266 decreasInternational journal of molecular sciencesModulation of K_V4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2.PMC9409462FPU17/02731PID2019-104366RB-C21PIE202180E073PRE2018-083280RYC2018-023837-ICB/11/00222PIE201820E1042019AEP148BES-2010-036573A-FQM-386-UGR20BIO2017-89523-RBES-2017-080184SAF2016-75021-RPID2020-114256RB-I00RTI2018-097189-B-C22PID2019-104366RB-C22PID2020-119805RB-I00Marin-Olivero IDaniel-Mozo MSocuellamos PGValenzuela CGutierrez-Rodriguez MMartin-Martinez MGonzalez-Vera JAMerinero YGCercos PPerez-Lara Ade Benito-Bueno AAlbert AIzquierdo COrte AfalseModulation of K_V4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2.The transient outward potassium current (<i>I</i>_tof) is generated by the activation of K_V4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by K_V4.3/KChIP2, K_V4.3/KChIP2/DPP6 and K_V4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected with cDNAs codifying for different proteins (K_V4.3/KChIP2, K_V4.3/KChIP2/DPP6 or K_V4.3/KChIP2/KCNE2), and the potassium currents were recorded using the whole-cell patch-clamp technique. IQM-266 decreas2022-01-01T00:00:00Z2022 Aug2026-05-09T03:16:23.058Z2024-10-16T04:12:54.873ZS-EPMC94094623601243810.3390/ijms23169170