{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu H"],"funding":["Xiao-Mao Zhou"],"pagination":["735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9409995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(8)"],"pubmed_abstract":["The diamondback moth (<i>Plutella xylostella</i>) is one of the most destructive lepidopteran pests of cruciferous vegetables, and insights into regulation of its physiological processes contribute towards the development of new pesticides against it. Thus, we investigated the regulatory functions of its β-adrenergic-like octopamine receptor (PxOctβ3). The open reading frame (ORF) of <i>PxOctβ3</i> was phylogenetically analyzed, and the levels of expression of the receptor mRNA were determined. This ORF was also cloned and expressed in HEK-293 cells. A series of octopamine receptor agonists and antagonists were tested against PxOctβ3. We showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative PCR showed that it was expressed at all developmental"],"journal":["Insects"],"pubmed_title":["Pharmacological Properties and Function of the PxOctβ3 Octopamine Receptor in <i>Plutella xylostella</i> (L.)."],"pmcid":["PMC9409995"],"funding_grant_id":["32172456"],"pubmed_authors":["Liu Z","Liu J","Zeng A","Ma H","Man Y","Zhu H","Zheng W","Zhou Y","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacological Properties and Function of the PxOctβ3 Octopamine Receptor in <i>Plutella xylostella</i> (L.).","description":"The diamondback moth (<i>Plutella xylostella</i>) is one of the most destructive lepidopteran pests of cruciferous vegetables, and insights into regulation of its physiological processes contribute towards the development of new pesticides against it. Thus, we investigated the regulatory functions of its β-adrenergic-like octopamine receptor (PxOctβ3). The open reading frame (ORF) of <i>PxOctβ3</i> was phylogenetically analyzed, and the levels of expression of the receptor mRNA were determined. This ORF was also cloned and expressed in HEK-293 cells. A series of octopamine receptor agonists and antagonists were tested against PxOctβ3. We showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative PCR showed that it was expressed at all developmental","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T15:25:05.469Z","creation":"2024-11-10T02:28:00.317Z"},"accession":"S-EPMC9409995","cross_references":{"pubmed":["36005359"],"doi":["10.3390/insects13080735"]}}