biostudies-literatureSun YJinding ChenScience and Technology Program of Guangzhou, ChinaKey Research Projects of Universities in Guangdong ProvinceGuangdong Major Project of Basic and Applied Basic ResearchLihua Xiao1303https://www.ebi.ac.uk/biostudies/studies/S-EPMC9412759biostudies-literatureUnknown10(8)Japanese encephalitis is a mosquito-borne zoonotic epidemic caused by the Japanese encephalitis virus (JEV). JEV is not only the leading cause of Asian viral encephalitis, but also one of the leading causes of viral encephalitis worldwide. To understand the genetic evolution and E protein characteristics of JEV, 263 suspected porcine JE samples collected from South China from 2011 to 2018 were inspected. It was found that 78 aborted porcine fetuses were JEV-nucleic-acid-positive, with a positive rate of 29.7%. Furthermore, four JEV variants were isolated from JEV-nucleic-acid-positive materials, namely, CH/GD2011/2011, CH/GD2014/2014, CH/GD2015/2015, and CH/GD2018/2018. The cell culture and virus titer determination of four JEV isolates showed that four JEV isolates could proliferate stablVaccinesGenomic Characteristics and E Protein Bioinformatics Analysis of JEV Isolates from South China from 2011 to 2018.PMC9412759No.2019KZDXM026202206010161No. 202206010161No.2020B03010300072019KZDXM0262020B0301030007Wu KDing HYan QChen JSun YZeng WNiu XFan SLi YZhao MLing BYi LZhao FfalseGenomic Characteristics and E Protein Bioinformatics Analysis of JEV Isolates from South China from 2011 to 2018.Japanese encephalitis is a mosquito-borne zoonotic epidemic caused by the Japanese encephalitis virus (JEV). JEV is not only the leading cause of Asian viral encephalitis, but also one of the leading causes of viral encephalitis worldwide. To understand the genetic evolution and E protein characteristics of JEV, 263 suspected porcine JE samples collected from South China from 2011 to 2018 were inspected. It was found that 78 aborted porcine fetuses were JEV-nucleic-acid-positive, with a positive rate of 29.7%. Furthermore, four JEV variants were isolated from JEV-nucleic-acid-positive materials, namely, CH/GD2011/2011, CH/GD2014/2014, CH/GD2015/2015, and CH/GD2018/2018. The cell culture and virus titer determination of four JEV isolates showed that four JEV isolates could proliferate stabl2022-01-01T00:00:00Z2022 Aug2026-05-08T03:11:38.024Z2024-11-08T20:15:10.511ZS-EPMC94127593601619210.3390/vaccines10081303