{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Cheng X"],"funding":["National Key Research and Development Program of China"],"pubmed_abstract":["The fate of a drug is not only the process of drug metabolism <i>in vivo</i> and <i>in vitro</i> but also the homeostasis of drug-exposed microbial communities may be disturbed. Anticoccidial drugs are widely used to combat the detrimental effects of protozoan parasites in the poultry industry. Salinomycin and ethanamizuril belong to two different classes of anticoccidial drugs. The effect of salinomycin and ethanamizuril on the microbiota of cecal content, manure compost, and soil remains unknown. Our results showed that although both salinomycin and ethanamizuril treatments suppressed some opportunistic pathogens, they failed to repair the great changes in chicken cecal microbial compositions caused by coccidia infection. Subsequently, the metabolite5 profiling of cecal content by LC-MS/"],"journal":["Frontiers in microbiology"],"pagination":["941259"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9413843"],"repository":["biostudies-literature"],"pubmed_title":["Effects of salinomycin and ethanamizuril on the three microbial communities <i>in vivo</i> and <i>in vitro</i>."],"pmcid":["PMC9413843"],"pubmed_authors":["Zheng H","Fei C","Zhang K","Wang C","Zhou W","Wang X","Cheng X"],"additional_accession":[]},"is_claimable":false,"name":"Effects of salinomycin and ethanamizuril on the three microbial communities <i>in vivo</i> and <i>in vitro</i>.","description":"The fate of a drug is not only the process of drug metabolism <i>in vivo</i> and <i>in vitro</i> but also the homeostasis of drug-exposed microbial communities may be disturbed. Anticoccidial drugs are widely used to combat the detrimental effects of protozoan parasites in the poultry industry. Salinomycin and ethanamizuril belong to two different classes of anticoccidial drugs. The effect of salinomycin and ethanamizuril on the microbiota of cecal content, manure compost, and soil remains unknown. Our results showed that although both salinomycin and ethanamizuril treatments suppressed some opportunistic pathogens, they failed to repair the great changes in chicken cecal microbial compositions caused by coccidia infection. Subsequently, the metabolite5 profiling of cecal content by LC-MS/","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T22:58:02.091Z","creation":"2024-11-10T03:38:19.872Z"},"accession":"S-EPMC9413843","cross_references":{"pubmed":["36033856"],"doi":["10.3389/fmicb.2022.941259"]}}