{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu H"],"funding":["NCI NIH HHS","NIH"],"pagination":["1298-1315"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9414288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(11)"],"pubmed_abstract":["Substantial progress has been made in understanding how tumors escape immune surveillance. However, few measures to counteract tumor immune evasion have been developed. Suppression of tumor antigen expression is a common adaptive mechanism that cancers use to evade detection and destruction by the immune system. Epigenetic modifications play a critical role in various aspects of immune invasion, including the regulation of tumor antigen expression. To identify epigenetic regulators of tumor antigen expression, we established a transplantable syngeneic tumor model of immune escape with silenced antigen expression and used this system as a platform for a CRISPR-Cas9 suppressor screen for genes encoding epigenetic modifiers. We found that disruption of the genes encoding either of the chromat"],"journal":["Cancer immunology research"],"pubmed_title":["Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity."],"pmcid":["PMC9414288"],"funding_grant_id":["RO1CA219670","RO1CA248896","R01 CA215471","R01 CA248896","R01 CA219670","RO1CA215471"],"pubmed_authors":["Ueberheide B","Sucker A","Zeck B","Zhang H","Schadendorf D","Deng J","Osman I","Wong KK","Chiriboga LA","Dowling CM","Cho H","Chen Z","Huang HY","Badri S","Zappile P","Tang S","Dolgalev I","Chen T","Velcheti V","Ranieri M","Ji H","Li F","Labbe K","Jin Y","Poirier JT","Tsirigos A","Jour G","Karatza A","Schalper KA","Lopez De Rodas Gregorio M","Hu H","Han H","Khodadadi-Jamayran A"],"additional_accession":[]},"is_claimable":false,"name":"Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity.","description":"Substantial progress has been made in understanding how tumors escape immune surveillance. However, few measures to counteract tumor immune evasion have been developed. Suppression of tumor antigen expression is a common adaptive mechanism that cancers use to evade detection and destruction by the immune system. Epigenetic modifications play a critical role in various aspects of immune invasion, including the regulation of tumor antigen expression. To identify epigenetic regulators of tumor antigen expression, we established a transplantable syngeneic tumor model of immune escape with silenced antigen expression and used this system as a platform for a CRISPR-Cas9 suppressor screen for genes encoding epigenetic modifiers. We found that disruption of the genes encoding either of the chromat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T13:08:56.235Z","creation":"2025-04-04T13:08:56.235Z"},"accession":"S-EPMC9414288","cross_references":{"pubmed":["34462284"],"doi":["10.1158/2326-6066.CIR-21-0543"]}}