biostudies-literatureRojas-Rechy MHFondo de Apoyo a la Investigación, Hospital Infantil de México Federico Gómez1685https://www.ebi.ac.uk/biostudies/studies/S-EPMC9414306biostudies-literatureUnknown10(8)Infections remain a major cause of morbidity and mortality among hematopoietic stem cell transplant (HSCT) recipients. Unlike Epstein-Barr Virus (EBV) and Human Cytomegalovirus (HCMV), Human Herpesvirus (HHV) 6, HHV7 and HHV8 are not routinely monitored in many centers, especially in the pediatric population of low-medium income countries. We screened EBV, HCMV, HHV6, HHV7 and HHV8 in 412 leukocytes-plasma paired samples from 40 pediatric patients assisted in a tertiary hospital in Mexico. Thirty-two underwent allo-HSCT, whereas eight received auto-HSCT. Overall viral detection frequencies in allo- and auto-HSCT were: EBV = 43.7% and 30.0%, HCMV = 5.0% and 6.7%, HHV6 = 7.9% and 20.0% and HHV7 = 9.7% and 23.3%. HHV8 was not detected in any sample. Interestingly, HHV6 and HHV7 were more freqMicroorganismsHerpesvirus Screening in Childhood Hematopoietic Transplant Reveals High Systemic Inflammation in Episodes of Multiple Viral Detection and an EBV Association with Elevated IL-1β, IL-8 and Graft-Versus-Host Disease.PMC9414306CONACyT FOSISS-2015-2-261307HIM/2016/089 SSA 1288HIM/2017/145 SSA 1469HIM/2016/021 SSA 1237HIM/2016/089HIM/2017/145Lopez-Martinez BRojas-Rechy MHMartinez-Ruiz GUMorales-Sanchez AFuentes-Panana EMGaytan-Morales FCastorena-Villa IParra-Ortega IEscamilla-Nunez MCPompa-Mera ENSanchez-Ponce YMendez-Tenorio AfalseHerpesvirus Screening in Childhood Hematopoietic Transplant Reveals High Systemic Inflammation in Episodes of Multiple Viral Detection and an EBV Association with Elevated IL-1β, IL-8 and Graft-Versus-Host Disease.Infections remain a major cause of morbidity and mortality among hematopoietic stem cell transplant (HSCT) recipients. Unlike Epstein-Barr Virus (EBV) and Human Cytomegalovirus (HCMV), Human Herpesvirus (HHV) 6, HHV7 and HHV8 are not routinely monitored in many centers, especially in the pediatric population of low-medium income countries. We screened EBV, HCMV, HHV6, HHV7 and HHV8 in 412 leukocytes-plasma paired samples from 40 pediatric patients assisted in a tertiary hospital in Mexico. Thirty-two underwent allo-HSCT, whereas eight received auto-HSCT. Overall viral detection frequencies in allo- and auto-HSCT were: EBV = 43.7% and 30.0%, HCMV = 5.0% and 6.7%, HHV6 = 7.9% and 20.0% and HHV7 = 9.7% and 23.3%. HHV8 was not detected in any sample. Interestingly, HHV6 and HHV7 were more freq2022-01-01T00:00:00Z2022 Aug2026-05-08T03:07:13.006Z2024-11-06T07:17:13.403ZS-EPMC94143063601410210.3390/microorganisms10081685