biostudies-literatureEscaja NMinisterio de Ciencia e Innovación5287https://www.ebi.ac.uk/biostudies/studies/S-EPMC9414646biostudies-literatureUnknown27(16)Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most extensively studied guanine quadruplex (G-quadruplex). Consequently, the G-tetrad is the most common and well-known tetrad. However, this is not the only possible arrangement of four nucleobases. A number of tetrads formed by the different nucleobases have been observed in experimental structures. In most cases, these tetrads occur in the context of G-quadruplex structures, either inserted between G-quartets, or as capping elements at the sides of the G-quadruplex core. In other cases, however, non-G tetrads are found in more unusual four strandeMolecules (Basel, Switzerland)Non-G Base Tetrads.PMC9414646PID2020-116620GB-I00Mir BEscaja NGonzalez CGaravis MfalseNon-G Base Tetrads.Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most extensively studied guanine quadruplex (G-quadruplex). Consequently, the G-tetrad is the most common and well-known tetrad. However, this is not the only possible arrangement of four nucleobases. A number of tetrads formed by the different nucleobases have been observed in experimental structures. In most cases, these tetrads occur in the context of G-quadruplex structures, either inserted between G-quartets, or as capping elements at the sides of the G-quadruplex core. In other cases, however, non-G tetrads are found in more unusual four strande2022-01-01T00:00:00Z2022 Aug2025-05-29T16:11:31.25Z2025-04-04T18:43:36.889ZS-EPMC94146463601452410.3390/molecules27165287