{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ko TS"],"funding":["NIBIB NIH HHS","NICHD NIH HHS","NHLBI NIH HHS","Children's Hospital of Philadelphia","NINDS NIH HHS","NIH HHS"],"pagination":["737"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9416552"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(8)"],"pubmed_abstract":["Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical repair. Here, we investigate correlations between non-invasive optical neuromonitoring of cerebral hemodynamics, which has recently shown promise for the prediction of postoperative white matter injury in this patient population, and invasive cerebral microdialysis biomarkers. We compared cerebral tissue oxygen saturation (StO<sub>2</sub>), relative total hemoglobin concentration (rTHC), and relative cerebral blood flow (rCBF) measured by optics against the microdialysis biomarkers of metabolic stress and injury (lactate-pyruvate ratio (LPR) and "],"journal":["Metabolites"],"pubmed_title":["Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass."],"pmcid":["PMC9416552"],"funding_grant_id":["F31-HD085731","R01-NS113945","R01 NS060653","T32 HL007915","K08 NS117897","Frontier Program","T32-HL007915","R01 HL141386","K08-NS117897","F31 HD085731","R01 NS113945","P41-EB015893","Cardiac Center","P41 EB015893","R01-NS060653","R01-HL141386"],"pubmed_authors":["Ko TS","Yodh AG","Benson EJ","Lin Y","Shade BC","White BR","Melchior RW","Aronowitz D","Mavroudis CD","Licht DJ","Starr JP","Baker WB","Rosenthal TM","Forti RM","Kilbaugh TJ","Morano VC","Mensah-Brown K","Lynch JM","Boorady TW","Schiavo KL","Gaynor JW"],"additional_accession":[]},"is_claimable":false,"name":"Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass.","description":"Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical repair. Here, we investigate correlations between non-invasive optical neuromonitoring of cerebral hemodynamics, which has recently shown promise for the prediction of postoperative white matter injury in this patient population, and invasive cerebral microdialysis biomarkers. We compared cerebral tissue oxygen saturation (StO<sub>2</sub>), relative total hemoglobin concentration (rTHC), and relative cerebral blood flow (rCBF) measured by optics against the microdialysis biomarkers of metabolic stress and injury (lactate-pyruvate ratio (LPR) and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-18T15:48:31.741Z","creation":"2025-04-07T02:38:41.344Z"},"accession":"S-EPMC9416552","cross_references":{"pubmed":["36005609"],"doi":["10.3390/metabo12080737"]}}