{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song Q"],"funding":["Science and Technology Department of Sichuan Province","Xihua University","SCIENCE AND TECHNOLOGY DEPARTMENT OF YIBIN"],"pagination":["5139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9416712"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(16)"],"pubmed_abstract":["An efficient continuous-flow nitration process of <i>o</i>-xylene at pilot scale was demonstrated. The effects of parameters such as temperature, ratio of H<sub>2</sub>SO<sub>4</sub> to HNO<sub>3</sub>, H<sub>2</sub>SO<sub>4</sub> concentration, flow rate, and residence time on the reaction were studied. Under the optimal conditions, the yield of products reached 94.1%, with a product throughput of 800 g/h. The main impurities of this continuous-flow nitration process were also studied in detail. Compared with batch process, phenolic impurity decreased from 2% to 0.1%, which enabled the omission of the alkaline solution washing step and thus reduced the wastewater emission. The method was also successfully applied to the nitrification of <i>p</i>-xylene, toluene, and chlorobenzene with goo"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Continuous-Flow Synthesis of Nitro-<i>o</i>-xylenes: Process Optimization, Impurity Study and Extension to Analogues."],"pmcid":["PMC9416712"],"funding_grant_id":["2021YFG0290","2021YFG2091","2021YG02","Z202030"],"pubmed_authors":["Chen J","Lei X","Wang S","Song Q","Xiang Y","Huang Q","Yang S","Wang J","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Continuous-Flow Synthesis of Nitro-<i>o</i>-xylenes: Process Optimization, Impurity Study and Extension to Analogues.","description":"An efficient continuous-flow nitration process of <i>o</i>-xylene at pilot scale was demonstrated. The effects of parameters such as temperature, ratio of H<sub>2</sub>SO<sub>4</sub> to HNO<sub>3</sub>, H<sub>2</sub>SO<sub>4</sub> concentration, flow rate, and residence time on the reaction were studied. Under the optimal conditions, the yield of products reached 94.1%, with a product throughput of 800 g/h. The main impurities of this continuous-flow nitration process were also studied in detail. Compared with batch process, phenolic impurity decreased from 2% to 0.1%, which enabled the omission of the alkaline solution washing step and thus reduced the wastewater emission. The method was also successfully applied to the nitrification of <i>p</i>-xylene, toluene, and chlorobenzene with goo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-05T10:25:07.062Z","creation":"2025-02-19T00:34:02.282Z"},"accession":"S-EPMC9416712","cross_references":{"pubmed":["36014379"],"doi":["10.3390/molecules27165139"]}}