biostudies-literatureLv FChinese Academy of SciencesKey Laboratory for Biomedical Effects of Nanomaterials and NanosafetyPriority Academic Program Development of Jiangsu Higher Education InstitutionsNational Natural Science Foundation of China1583-1589https://www.ebi.ac.uk/biostudies/studies/S-EPMC9416945biostudies-literatureUnknown2(4)Effective alcohol detection represents a substantial concern not only in the context of personal and automobile safety but also in clinical settings as alcohol is a contributing factor in a wide range of health complications including various types of liver cirrhoses, strokes, and cardiovascular diseases. Recently, many kinds of nanomaterials with enzyme-like properties have been widely used as biosensors. Herein, we have developed a convenient detection method that combines Au@PtRu nanozymes and alcohol oxidase (AOx). We found that the Au@PtRu nanorods exhibited peroxidase-like catalytic activity that was much higher than the catalytic activities of the Au and Au@Pt nanorods. The Au@PtRu nanorod-catalyzed generation of hydroxyl radicals in the presence of H₂O₂ was usNanoscale advancesA convenient detection system consisting of efficient Au@PtRu nanozymes and alcohol oxidase for highly sensitive alcohol biosensing.PMC9416945NSKF201806319713205180103017KJB430029Liang SLv FGu HTian XCao YYin JJGong YDeng YfalseA convenient detection system consisting of efficient Au@PtRu nanozymes and alcohol oxidase for highly sensitive alcohol biosensing.Effective alcohol detection represents a substantial concern not only in the context of personal and automobile safety but also in clinical settings as alcohol is a contributing factor in a wide range of health complications including various types of liver cirrhoses, strokes, and cardiovascular diseases. Recently, many kinds of nanomaterials with enzyme-like properties have been widely used as biosensors. Herein, we have developed a convenient detection method that combines Au@PtRu nanozymes and alcohol oxidase (AOx). We found that the Au@PtRu nanorods exhibited peroxidase-like catalytic activity that was much higher than the catalytic activities of the Au and Au@Pt nanorods. The Au@PtRu nanorod-catalyzed generation of hydroxyl radicals in the presence of H₂O₂ was us2020-01-01T00:00:00Z2020 Apr2025-04-04T03:25:23.158Z2025-02-19T01:37:48.51ZS-EPMC94169453613231810.1039/d0na00002g