{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ohlstrom DJ"],"funding":["NHLBI NIH HHS"],"pagination":["14560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9418138"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Acute respiratory distress syndrome is a heterogeneous pathophysiological process responsible for significant morbidity and mortality in pediatric intensive care patients. Diagnosis is defined by clinical characteristics that identify the syndrome after development. Subphenotyping patients at risk of progression to ARDS could provide the opportunity for therapeutic intervention. microRNAs, non-coding RNAs stable in circulation, are a promising biomarker candidate. We conducted a single-center prospective cohort study to evaluate random forest classification of microarray-quantified circulating microRNAs in critically ill pediatric patients. We additionally selected a sub-cohort for parallel metabolomics profiling as a pilot study for concurrent use of miRNAs and metabolites as circulating "],"journal":["Scientific reports"],"pubmed_title":["Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study."],"pmcid":["PMC9418138"],"funding_grant_id":["R01 HL119533","HL124103","K24 HL150630","HL119533","R35 HL139726"],"pubmed_authors":["Vohwinkel CU","Hernandez-Lagunas L","Karimpour-Fard A","Ohlstrom DJ","Nozik ES","Sul C","Mourani PM","Carpenter TC","Sucharov CC"],"additional_accession":[]},"is_claimable":false,"name":"Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study.","description":"Acute respiratory distress syndrome is a heterogeneous pathophysiological process responsible for significant morbidity and mortality in pediatric intensive care patients. Diagnosis is defined by clinical characteristics that identify the syndrome after development. Subphenotyping patients at risk of progression to ARDS could provide the opportunity for therapeutic intervention. microRNAs, non-coding RNAs stable in circulation, are a promising biomarker candidate. We conducted a single-center prospective cohort study to evaluate random forest classification of microarray-quantified circulating microRNAs in critically ill pediatric patients. We additionally selected a sub-cohort for parallel metabolomics profiling as a pilot study for concurrent use of miRNAs and metabolites as circulating ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T13:46:37.408Z","creation":"2025-04-04T13:46:37.408Z"},"accession":"S-EPMC9418138","cross_references":{"pubmed":["36028738"],"doi":["10.1038/s41598-022-15476-0"]}}