biostudies-literatureBao GGouvernement du Canada | Natural Sciences and Engineering Research Council of CanadaU.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication DisordersNIDCD NIH HHSGouvernement du Canada | Canadian Institutes of Health ResearchCIHR5035https://www.ebi.ac.uk/biostudies/studies/S-EPMC9418157biostudies-literatureUnknown13(1)Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removNature communicationsLiquid-infused microstructured bioadhesives halt non-compressible hemorrhage.PMC9418157R01 DC014461R01 DC018577R01-DC018577R01 DC005788PJT-180232R01-DC014461RGPIN-2018-04146R01-DC005788Kastrup CLi JStrong MGao ZHValiei AJiang SMa ZMongeau LGao QYang ZAli-Mohamad NAmabili MBao GCau MfalseLiquid-infused microstructured bioadhesives halt non-compressible hemorrhage.Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant remov2022-01-01T00:00:00Z2022 Aug2026-06-03T10:27:21.14Z2025-06-01T12:08:25.886ZS-EPMC94181573602851610.1038/s41467-022-32803-1