biostudies-literatureUnknown4(4)Baum M<h4>Background</h4>MRSA is a major global healthcare problem. In 2011, a new <i>mec</i> variant designated <i>mecC</i> was described, presenting partial identity at the DNA level, thus undetectable by routine <i>mecA</i> PCR.<h4>Objectives</h4>Until now, no reliable information regarding <i>mecC</i> MRSA prevalence was available in Israel. In this study, to the best of our knowledge, we describe the first case of <i>mecC</i> MRSA in Israel, with focus on genomic analysis and global context.<h4>Methods</h4>The <i>mecC</i> MRSA isolate was analysed by WGS with focus on phylogeny, global contextualization, virulence and resistance genes. The strain was characterized by antibiotic susceptibility testing, <i>spa</i> typing and presence of <i>mecA/C</i> and <i>pvl</i> genes.<h4>Results</h4>An MRJAC-antimicrobial resistancedlac085https://www.ebi.ac.uk/biostudies/studies/S-EPMC9418563biostudies-literature<i>mecC</i> MRSA in Israel-genomic analysis, prevalence and global perspective.PMC9418563Prajgrod GValinsky LBaum MRokney AAnuka ETreygerman Ofalse<i>mecC</i> MRSA in Israel-genomic analysis, prevalence and global perspective.<h4>Background</h4>MRSA is a major global healthcare problem. In 2011, a new <i>mec</i> variant designated <i>mecC</i> was described, presenting partial identity at the DNA level, thus undetectable by routine <i>mecA</i> PCR.<h4>Objectives</h4>Until now, no reliable information regarding <i>mecC</i> MRSA prevalence was available in Israel. In this study, to the best of our knowledge, we describe the first case of <i>mecC</i> MRSA in Israel, with focus on genomic analysis and global context.<h4>Methods</h4>The <i>mecC</i> MRSA isolate was analysed by WGS with focus on phylogeny, global contextualization, virulence and resistance genes. The strain was characterized by antibiotic susceptibility testing, <i>spa</i> typing and presence of <i>mecA/C</i> and <i>pvl</i> genes.<h4>Results</h4>An MR2022-01-01T00:00:00Z2022 Aug2025-04-05T00:42:36.574Z2025-02-19T03:29:06.119ZS-EPMC94185633604298010.1093/jacamr/dlac085