{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(8)"],"submitter":["McCauley KE"],"pubmed_abstract":["Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) samples, we identify four compositionally and functionally distinct Lactobacillus-dominated vaginal microbiota clusters (VCs) that relate to prenatal maternal health and exposures and infant serum immunoglobulin E (IgE) status at 1 year. Variance in bacteria shared between mother and infant pairs relate to VCs, maternal allergy/asthma status, and infant IgE levels. Heritable bacterial gene pathways associated with infant IgE include fatty acid synthesis and histamine and tryptophan degradat"],"journal":["Cell reports. Medicine"],"pagination":["100713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9418802"],"repository":["biostudies-literature"],"pubmed_title":["Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy."],"pmcid":["PMC9418802"],"pubmed_authors":["Ownby DR","ECHO Children’s Respiratory and Environmental Workgroup","Johnson CC","Barnes K","Kim H","Lynch KV","Burt TD","McCauley KE","Gern JE","Seroogy CM","Panzer AR","Halkias J","Bendixsen C","Fadrosh DW","Jones K","Boushey HA","Fujimura KE","Rackaityte E","Mendoza VF","LaMere B","Lin DL","Lynch SV"],"additional_accession":[]},"is_claimable":false,"name":"Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy.","description":"Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) samples, we identify four compositionally and functionally distinct Lactobacillus-dominated vaginal microbiota clusters (VCs) that relate to prenatal maternal health and exposures and infant serum immunoglobulin E (IgE) status at 1 year. Variance in bacteria shared between mother and infant pairs relate to VCs, maternal allergy/asthma status, and infant IgE levels. Heritable bacterial gene pathways associated with infant IgE include fatty acid synthesis and histamine and tryptophan degradat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-21T14:48:19.191Z","creation":"2025-04-21T14:48:19.191Z"},"accession":"S-EPMC9418802","cross_references":{"pubmed":["35932762"],"doi":["10.1016/j.xcrm.2022.100713"]}}