{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Voylov DN"],"funding":["U.S. Department of Energy","Office of Science","Oak Ridge National Laboratory"],"pagination":["3392-3399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9419720"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(9)"],"pubmed_abstract":["Tip-enhanced Raman spectroscopy (TERS) has been established as one the most efficient analytical techniques for probing vibrational states with nanoscale resolution. While TERS may be a source of unique information about chemical structure and interactions, it has a limited use for materials with rough or sticky surfaces. Development of the TERS approach utilizing a non-contact scanning probe microscopy mode can significantly extend the number of applications. Here we demonstrate a proof of the concept and feasibility of a non-contact TERS approach and test it on various materials. Our experiments show that non-contact TERS can provide 10 nm spatial resolution and a Raman signal enhancement factor of 10<sup>5</sup>, making it very promising for chemical imaging of materials with high aspec"],"journal":["Nanoscale advances"],"pubmed_title":["Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications."],"pmcid":["PMC9419720"],"funding_grant_id":["DE-AC05-00OR22725","SEED Program","Basic Energy Sciences, Materials Science &amp; Enginee"],"pubmed_authors":["Vlassiouk I","Narayanan R","Shulga YM","Sumpter BG","Thiyagarajan T","Volodin A","Lavrik NV","Sokolov AP","Polizos G","Kisliuk A","Miller DD","Voylov DN","Bocharova V"],"additional_accession":[]},"is_claimable":false,"name":"Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications.","description":"Tip-enhanced Raman spectroscopy (TERS) has been established as one the most efficient analytical techniques for probing vibrational states with nanoscale resolution. While TERS may be a source of unique information about chemical structure and interactions, it has a limited use for materials with rough or sticky surfaces. Development of the TERS approach utilizing a non-contact scanning probe microscopy mode can significantly extend the number of applications. Here we demonstrate a proof of the concept and feasibility of a non-contact TERS approach and test it on various materials. Our experiments show that non-contact TERS can provide 10 nm spatial resolution and a Raman signal enhancement factor of 10<sup>5</sup>, making it very promising for chemical imaging of materials with high aspec","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-18T15:47:32.452Z","creation":"2025-02-19T01:38:29.338Z"},"accession":"S-EPMC9419720","cross_references":{"pubmed":["36133556"],"doi":["10.1039/c9na00322c"]}}