{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["146(9)"],"submitter":["Hagstrom E"],"pubmed_abstract":["<h4>Background</h4>Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain.<h4>Methods</h4>The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfata"],"journal":["Circulation"],"pagination":["657-672"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9422774"],"repository":["biostudies-literature"],"pubmed_title":["Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab."],"pmcid":["PMC9422774"],"pubmed_authors":["Kishi K","Prieto JC","Costamagna O","Haniffa R","Cornel JH","Ronner E","Aidar Ayoub JC","Hagstrom E","Galski T","Kartalis A","Caccavo A","Sherwood MW","Licciardello G","Carrion Chambilla JM","Ilic S","Kornowski R","Accini Mendoza JL","Leimbach W","Cools F","Ranjith N","Kristensen KS","Alexandru TM","Perlmutter N","Rodriguez De Leon ER","Viktorova I","White L","White M","Raffo CA","Drouet E","Farhat N","Wei M","Massey C","Saaiman JA","Vijay N","May W","Marx N","Marx R","Hanotin C","May O","Bagriy A","Yu Y","Starmer 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Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.","description":"<h4>Background</h4>Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain.<h4>Methods</h4>The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfata","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-28T06:47:14.865Z","creation":"2025-02-19T03:28:59.541Z"},"accession":"S-EPMC9422774","cross_references":{"pubmed":["35770629"],"doi":["10.1161/CIRCULATIONAHA.121.057807"]}}