biostudies-literatureUnknown146(9)Hagstrom E<h4>Background</h4>Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain.<h4>Methods</h4>The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfataCirculation657-672https://www.ebi.ac.uk/biostudies/studies/S-EPMC9422774biostudies-literatureApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.PMC9422774Kishi KPrieto JCCostamagna OHaniffa RCornel JHRonner EAidar Ayoub JCHagstrom EGalski TKartalis ACaccavo ASherwood MWLicciardello GCarrion Chambilla JMIlic SKornowski RAccini Mendoza JLLeimbach WCools FRanjith NKristensen KSAlexandru TMPerlmutter NRodriguez De Leon ERViktorova IWhite LWhite MRaffo CADrouet EFarhat NWei MMassey CSaaiman JAVijay NMay WMarx NMarx RHanotin CMay OBagriy AYu YStarmer GSarkar DHalvorsen SHahalis GZhu HPalvarini MKirma CKondo NIZhu JHsieh ICSato KRamin EKralova KMahal SLuciardi HLRao SJeserich MWaltman Jde Souza JAPawlowicz LAgarwal HKhabeishvili GVazquez ESHaddad TGuzman PNChen YMoriarty PMLipko JAShinke TMontecinos HBengston JGiordano JAChen JPoulsen SHWlodarczak APersic VZvi VDe Leon MGTricoci PSharma MChen DZaman AMachado LVallejo GSNelson WKaralis IArif IMalhotra VPollock SMuller CBanuru SArango Benecke JLMuller GAbdullakutty JWaites JHNieminen MSVico MLXiang MPaterlini GAMurphy JTasic NWolf LPerez LMurphy SHodes ZRosas ELClaeys MMilicic DMaia LNLazov PVRepincay JLaxson Dvan Diepen SFPSouza WKAboyans VZuran IRokyta RRondel CLubinski ADeVore ADPonnamperuma CRozeman PCuccia CZwart PAlonso ABinde RHunter JGorny JPonce GAssi NYanez MHwang JJRodes-Cabau JTosic BPMostovoy YWeißbrodt MPanchal VShinde RChandna HShvarts YCastadot MFilho PPBhansali PCalderon Ticona JRHeitzer TChaitman BNahhas AShaw MLeclercq FViolini RShaw JDandillaya RNovo SCamacho Cosavalente LABraganza DBerk MSotnikova TMittal SColquhoun DSirisena TPeng DBashir RPellegrin ACalabro PPayeras ACMarcus JElliott JCotruta RMody FBregeault MFUngi IPerez Rios JACaruso OCJovin IEhud CShalaev SStapleton DJoshi ABSethi SXenakis MKerkar PSkorski 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MKamensky GZhang RPontaga NNishibe AShou XSikic JSaminski KJure HODodic SOurliac APirenne BYin WHLorenzato CFrey BMarusincova IElias NGospodinov MDavies RElias MBarrera Silva SIKrasowski WMusumeci GKnickelbine TKaewsuwanna PSionis DLove MBasart DMasutani MGoyal NKKanorsky SChu AMorais JMunusamy VVohra RFernandez MStriekwold HSoward AZhou YShustov SVelcheva ESNogareda GFilardi PPStaneta PVidovich MAlves De Lima AEPancholy SCoching RMKumar VRubenstein HLillis LAtar SKumar PLepage SLotan CWhitaker JArandjelovic AOlivari ZMorales UGurevich VBotelho RVAhuad Guerrero RAKandasamy BRosenson RTan ESun YMathews REndsley PMatuska JPagava ZCarroll PALaufs UNijmeijer RSawhney JDahl CXu BHarrison RWHarding SAhremark UChizhov PRose GBougon NLabroo ARacca VShimatani YMonteiro PWesterhausen DNegron Miguel SANociar JSingsaas EGKumar ASzarek MBhatt DLArambula RSSuh DInce CWaltenberger JMilitaru CHoppe USiu DCHeath MSenni MHalle BXu DAcevedo MFisher DFisher RFisher NHuikuri HLeonardi SMthombeni BXu 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JCNicolau JCAkyea-Djamson AFurukawa YSchuchard TFell DTang I-Shing JSandhu MDo RMileta DStrozzi MFernandez Ruiz RLCha JSzwed HSijbrands EJGRatky CZhao XNagy LZhao SMatei AVManvelian GLiem AACorbett CGonzalez Diaz BBelhassane AManzur Jatin FGAiraksinen JMetra MYoon JHVedin OConstantinescu MCKosmachova ECohen SDion DGarcia Duran ROChachalis GTov NGosselin GStellbrink CHeinc PVardas PHedman AReshetko OMejic-Krstulovic SAlbert SToledo PSasiela WJOrcajo NAClifford PKline GPotthoff SJaramillo NZhong YZahger DIyengar SSLandeo JHKrichmar PPintaric HAnnam SZrazhevsky KMurillo FCOomman AHermans WRMetwally LRodriguez JBWitt NGarcia-Dorado DHsiang Lin WTahk SJValdovinos MParepa IRNeto JAMHart HUeda YMeloni CManakshe GVRoosen JGarcia Brasca DFStasiewski AOliveira JKuchar JStringfellow KMesquita Bastos JWilkins GMaskon OGielen SEdward KWerner CCzerski TKoldas LFeenema-Aradema MShetty SHeidenreich LMendonca CMakoali Makotoko EHurtig UMcClanahan MABarakovic FGuillou SConrad GMatthews AChristopher DErsanli MTonnessen GHenderson DGoch AFazlibegovic EKim CBrodison AJafar ZKibarskis AGuneri SMiklaszewicz BSoopold UCheng XAdamkova VCommerford PJSpinar JWerner NLeggewie SZong WPuri SPellan VBudaj ACarlson EGuardigli GUshakov OLevite HStankovic AFaggiano PMarin FBerdan LKim YTreasure Ii CD'Urso MRorick TBerli MASinha DAbbate AKapin TLambert CPerthuis AVakaluyk IBrabham DKarpov YCarlos PHata YJanosik DLuquez HAKushnir MSoroka EZainea MCambier PKawakami ALovric Bencic MValiris JTurk SProkhorov AMansourati JSubherwal SMendis SLandzberg JTyrenko VVDing CKillat HBhagwat RMotovska ZDuronto EARogers WGoodman SGTze-Kay Yan AGislason GAppel KFRaisinghani ADodds Iii GJoshi PSchellenberg DBrigui INielsen PKDaniels CJaiwal GTakeda YScalise FChaleff FLarry JBouancheau CRajapaksha ALopez-Jaramillo PGabor Kiss RSzigeti ZOlexa PfalseApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.<h4>Background</h4>Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain.<h4>Methods</h4>The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfata2022-01-01T00:00:00Z2022 Aug2026-05-28T06:47:14.865Z2025-02-19T03:28:59.541ZS-EPMC94227743577062910.1161/CIRCULATIONAHA.121.057807