{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Schnell AP"],"pubmed_abstract":["The viral transactivator Tax plays a key role in HTLV-1 reactivation and <i>de novo</i> infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells to the host's immune response. However, following treatment with Valproate proviral load decreases in patients with HAM/TSP were only transient. Here, we hypothesize that other compounds, including more potent and selective HDACi, might prove superior to Valproate in manipulating Tax expression. Thus, a panel of HDACi (Vorinostat/SAHA/Zolinza, Panobinostat/LBH589/Farydak, Belinostat/PXD101/Beleodaq, Valproate, Entinostat/MS-275, Romidepsin/FK228/Istodax, and MC1568) was selected and tested for toxicity and potency in enhancing Tax ex"],"journal":["Frontiers in immunology"],"pagination":["978800"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9424546"],"repository":["biostudies-literature"],"pubmed_title":["HDAC inhibitors Panobinostat and Romidepsin enhance <i>tax</i> transcription in HTLV-1-infected cell lines and freshly isolated patients' T-cells."],"pmcid":["PMC9424546"],"pubmed_authors":["Aristodemou A","Taylor GP","Bangham CRM","Kohrt S","Schnell AP","Thoma-Kress AK"],"additional_accession":[]},"is_claimable":false,"name":"HDAC inhibitors Panobinostat and Romidepsin enhance <i>tax</i> transcription in HTLV-1-infected cell lines and freshly isolated patients' T-cells.","description":"The viral transactivator Tax plays a key role in HTLV-1 reactivation and <i>de novo</i> infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells to the host's immune response. However, following treatment with Valproate proviral load decreases in patients with HAM/TSP were only transient. Here, we hypothesize that other compounds, including more potent and selective HDACi, might prove superior to Valproate in manipulating Tax expression. Thus, a panel of HDACi (Vorinostat/SAHA/Zolinza, Panobinostat/LBH589/Farydak, Belinostat/PXD101/Beleodaq, Valproate, Entinostat/MS-275, Romidepsin/FK228/Istodax, and MC1568) was selected and tested for toxicity and potency in enhancing Tax ex","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T21:51:31.044Z","creation":"2025-04-04T21:51:31.044Z"},"accession":"S-EPMC9424546","cross_references":{"pubmed":["36052071"],"doi":["10.3389/fimmu.2022.978800"]}}