{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(8)"],"submitter":["Jex N"],"pubmed_abstract":["<h4>Background</h4>Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion.<h4>Case summary</h4>A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries.<h4>Discussion</h4>Comorbidity with T2D and apical HCM resulted in a significant increase in m"],"journal":["European heart journal. Case reports"],"pagination":["ytac347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9425848"],"repository":["biostudies-literature"],"pubmed_title":["A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy."],"pmcid":["PMC9425848"],"pubmed_authors":["Chowdhary A","Thirunavukarasu S","Jex N","Levelt E"],"additional_accession":[]},"is_claimable":false,"name":"A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy.","description":"<h4>Background</h4>Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion.<h4>Case summary</h4>A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries.<h4>Discussion</h4>Comorbidity with T2D and apical HCM resulted in a significant increase in m","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-18T22:27:31.56Z","creation":"2025-04-07T10:13:35.35Z"},"accession":"S-EPMC9425848","cross_references":{"pubmed":["36045647"],"doi":["10.1093/ehjcr/ytac347"]}}