biostudies-literatureRosenkranz MANICHD NIH HHSNCCIH NIH HHSNHLBI NIH HHS108226https://www.ebi.ac.uk/biostudies/studies/S-EPMC9426565biostudies-literatureUnknown167Psychological stress, an important contributor to asthma morbidity, potentiates the immune response to allergen, but the brain mechanisms mediating this response are not fully understood. The amygdala is likely to play an important role, given its sensitivity to threat and connectivity with descending immune modulatory pathways. In this study, we recruited thirty asthmatic participants and examined glucose metabolism in the amygdala, using [F-18]fluorodeoxyglucose positron emission tomography, during a laboratory stressor. Stress hormone and airway inflammatory measurements were also acquired. Results showed that activity in the amygdala was significantly increased during the stressor, compared to a matched control task (p < .05 corrected). Moreover, the increase in amygdala activity was aBiological psychologyRole of amygdala in stress-induced upregulation of airway IL-1 signaling in asthma.PMC9426565K01 AT006202R01 HL123284P30 HD003352P01 AT004952Rosenkranz MAJarjour NNChristian BTBusse WWGresham LEsnault SDavidson RJfalseRole of amygdala in stress-induced upregulation of airway IL-1 signaling in asthma.Psychological stress, an important contributor to asthma morbidity, potentiates the immune response to allergen, but the brain mechanisms mediating this response are not fully understood. The amygdala is likely to play an important role, given its sensitivity to threat and connectivity with descending immune modulatory pathways. In this study, we recruited thirty asthmatic participants and examined glucose metabolism in the amygdala, using [F-18]fluorodeoxyglucose positron emission tomography, during a laboratory stressor. Stress hormone and airway inflammatory measurements were also acquired. Results showed that activity in the amygdala was significantly increased during the stressor, compared to a matched control task (p < .05 corrected). Moreover, the increase in amygdala activity was a2022-01-01T00:00:00Z2022 Jan2025-04-19T18:09:41.952Z2025-04-19T18:09:41.952ZS-EPMC94265653480056110.1016/j.biopsycho.2021.108226