biostudies-literatureXiao MNatural Science Foundation of Chongqing9430509https://www.ebi.ac.uk/biostudies/studies/S-EPMC9427271biostudies-literatureUnknown2022Tripartite motif (TRIM) protein family proteins contain more than 80 members in humans, and most of these proteins exhibit E3 ubiquitin ligase activity mediated through a RING finger domain. Their biological functions are very complex, and they perform diverse functions in cell evolution processes, such as intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy, and carcinogenesis. Tripartite motif-containing protein 2 (TRIM2), a member of the TRIM superfamily, is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3. TRIM2 functions as an E3 ubiquitin ligase. Current studies have shown that TRIM2 can play roles in neuroprotection, neuronal rapid ischemic tolerance, antiviral responses, neurological diseases, etc. MoreovBioMed research internationalExpression and Role of TRIM2 in Human Diseases.PMC9427271cstc2019jcyj-msxmX0732cstc2017shms-zdyf0319Yang ZXiao MLi JHe XWang DLiu QfalseExpression and Role of TRIM2 in Human Diseases.Tripartite motif (TRIM) protein family proteins contain more than 80 members in humans, and most of these proteins exhibit E3 ubiquitin ligase activity mediated through a RING finger domain. Their biological functions are very complex, and they perform diverse functions in cell evolution processes, such as intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy, and carcinogenesis. Tripartite motif-containing protein 2 (TRIM2), a member of the TRIM superfamily, is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3. TRIM2 functions as an E3 ubiquitin ligase. Current studies have shown that TRIM2 can play roles in neuroprotection, neuronal rapid ischemic tolerance, antiviral responses, neurological diseases, etc. Moreov2022-01-01T00:00:00Z20222025-04-19T15:38:53.964Z2025-02-19T03:29:00.864ZS-EPMC94272713605148610.1155/2022/9430509