{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Spitznagel T"],"pubmed_abstract":["<h4>Background</h4>Indication biopsies for deterioration of kidney allograft function often require follow-up biopsies to assess treatment response or lack of improvement. Immune-mediated injury, namely borderline rejection (BLR), T-cell mediated rejection (TCMR), or antibody-mediated rejection (ABMR), results from preformed or <i>de novo</i> alloreactivity due to donor and recipient HLA-mismatches. The impact of HLA-mismatches on alloreactivity is determined by highly immunogenic HLA-epitopes.<h4>Methods</h4>We analyzed 123 kidney transplant recipients (KTRs) from 2009 to 2019 who underwent a first indication and a follow-up biopsy. KTRs were divided into three groups according to the first biopsy: No rejection (NR)/BLR (n=68); TCMR (n=21); ABMR (n=34). The HLA-derived epitope-mismatches "],"journal":["Frontiers in immunology"],"pagination":["949933"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9428698"],"repository":["biostudies-literature"],"pubmed_title":["PIRCHE-II scores prove useful as a predictive biomarker among kidney transplant recipients with rejection: An analysis of indication and follow-up biopsies."],"pmcid":["PMC9428698"],"pubmed_authors":["von Moos S","Schachtner T","Nilsson J","Kaufmann YL","Matter LS","Spitznagel T"],"additional_accession":[]},"is_claimable":false,"name":"PIRCHE-II scores prove useful as a predictive biomarker among kidney transplant recipients with rejection: An analysis of indication and follow-up biopsies.","description":"<h4>Background</h4>Indication biopsies for deterioration of kidney allograft function often require follow-up biopsies to assess treatment response or lack of improvement. Immune-mediated injury, namely borderline rejection (BLR), T-cell mediated rejection (TCMR), or antibody-mediated rejection (ABMR), results from preformed or <i>de novo</i> alloreactivity due to donor and recipient HLA-mismatches. The impact of HLA-mismatches on alloreactivity is determined by highly immunogenic HLA-epitopes.<h4>Methods</h4>We analyzed 123 kidney transplant recipients (KTRs) from 2009 to 2019 who underwent a first indication and a follow-up biopsy. KTRs were divided into three groups according to the first biopsy: No rejection (NR)/BLR (n=68); TCMR (n=21); ABMR (n=34). The HLA-derived epitope-mismatches ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T12:11:00.163Z","creation":"2025-04-05T12:11:00.163Z"},"accession":"S-EPMC9428698","cross_references":{"pubmed":["36059499"],"doi":["10.3389/fimmu.2022.949933"]}}