{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stagel K"],"funding":["Austrian Science Fund FWF"],"pagination":["11215-11222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9428890"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(34)"],"pubmed_abstract":["Herein, we present a novel approach for the halide-free, continuous-flow preparation of hydrophobic ionic liquids (ILs) relying on the bis(trifluoromethanesulfonyl)imide (bistriflimide, NTf<sub>2</sub> <sup>-</sup>) anion. The simple yet fast two-step synthetic route, which involves the formation of different alkyl bistriflimides (R<sup>4</sup>NTf<sub>2</sub>), followed by the quaternization with an amine nucleophile, led to the desired ILs in high yields and excellent purities without any byproduct formation. The variable alkyl chain (R<sup>4</sup>) length and the broad range of the applicable nucleophiles (R<sup>1</sup>R<sup>2</sup>R<sup>3</sup>N) offer considerable flexibility to the synthetic protocol. The quaternization can be performed under solvent-free conditions; moreover, the hom"],"journal":["ACS sustainable chemistry & engineering"],"pubmed_title":["Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids."],"pmcid":["PMC9428890"],"funding_grant_id":["P 32882"],"pubmed_authors":["Szpecht A","Zielinski D","Bica-Schroder K","Smiglak M","Stagel K","Schnurch M"],"additional_accession":[]},"is_claimable":false,"name":"Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids.","description":"Herein, we present a novel approach for the halide-free, continuous-flow preparation of hydrophobic ionic liquids (ILs) relying on the bis(trifluoromethanesulfonyl)imide (bistriflimide, NTf<sub>2</sub> <sup>-</sup>) anion. The simple yet fast two-step synthetic route, which involves the formation of different alkyl bistriflimides (R<sup>4</sup>NTf<sub>2</sub>), followed by the quaternization with an amine nucleophile, led to the desired ILs in high yields and excellent purities without any byproduct formation. The variable alkyl chain (R<sup>4</sup>) length and the broad range of the applicable nucleophiles (R<sup>1</sup>R<sup>2</sup>R<sup>3</sup>N) offer considerable flexibility to the synthetic protocol. The quaternization can be performed under solvent-free conditions; moreover, the hom","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-25T19:11:37.046Z","creation":"2025-04-06T07:50:04.647Z"},"accession":"S-EPMC9428890","cross_references":{"pubmed":["36061098"],"doi":["10.1021/acssuschemeng.2c02871"]}}