{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lanz B"],"funding":["Swiss National Science Foundation","NIBIB NIH HHS","NIA NIH HHS","National Institutes of Health (NIH)","NINDS NIH HHS","National Institutes of Health"],"pubmed_abstract":["In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical <sup>1</sup>H, <sup>31</sup>P and <sup>13</sup>C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts' consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical comp"],"journal":["NMR in biomedicine"],"pagination":["e4325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9429976"],"repository":["biostudies-literature"],"pubmed_title":["Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations."],"pmcid":["PMC9429976"],"funding_grant_id":["U01 NS100620","BTRC P41 EB027061","P30 AG062677","P41 EB027061","AG063911, KK","310030","AG062677","NS080816","NS100620","P30 NS076408","173222","310030_173222, CC","R01 NS080816","U19 AG063911","P30 NS076408 MM"],"pubmed_authors":["Lutz NW","Henry PG","Lee P","Experts' Working Group on Magnetic resonance spectroscopy in the rodent","Tkac I","Kara F","Williams SR","Mlynarik V","Ligneul C","Choi IY","Cudalbu C","Oz G","Behar K","Xin L","Gruetter R","Valette J","Dreher W","Rasche V","Abaei A","Experts' Working Group on Magnetic resonance spectroscopy in the","Braissant O","Marjanska M","Lanz B","Boumezbeur F","Klaunberg BA","Deelchand DK","Lindquist DM","Kantarci K"],"additional_accession":[]},"is_claimable":false,"name":"Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.","description":"In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical <sup>1</sup>H, <sup>31</sup>P and <sup>13</sup>C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts' consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical comp","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-21T18:59:27.263Z","creation":"2025-02-19T00:41:54.916Z"},"accession":"S-EPMC9429976","cross_references":{"pubmed":["33565219"],"doi":["10.1002/nbm.4325"]}}