{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiong K"],"funding":["Key Research and Development Projects of Science and Technology Department of Sichuan Province","National Natural Science Foundation of China","SPDST | Applied Basic Research Program of Sichuan Province"],"pagination":["e0078222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9430244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["The cross-kingdom interactions between Candida albicans and Actinomyces viscosus play critical roles in root caries. However, the key pathway by which C. albicans regulates its interactions with A. viscosus is unclear. Here, we first employed 39 volunteers with root caries and 37 caries-free volunteers, and found that the abundances of C. albicans and A. viscosus were significantly increased in the individuals with root caries and showed a strong positive correlation. Their dual-species combination synergistically promoted biofilm formation and root caries in rats. The arginine biosynthesis pathway of C. albicans was significantly upregulated in dual-species biofilms and dental plaques from another 10 root caries volunteers compared with the 10 caries-free volunteers. The exogenous additio"],"journal":["Microbiology spectrum"],"pubmed_title":["The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries."],"pmcid":["PMC9430244"],"funding_grant_id":["81870778","82071111","2021YFQ0064","2020YFSY0019","81991500","81600858","2020YJ0227","81991501"],"pubmed_authors":["Yang X","Xiong K","Li Y","Zou L","Zhu H","Deng L","Chen X","Yan Y","Chi Y","Zhou X","Ren B","Ji M"],"additional_accession":[]},"is_claimable":false,"name":"The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries.","description":"The cross-kingdom interactions between Candida albicans and Actinomyces viscosus play critical roles in root caries. However, the key pathway by which C. albicans regulates its interactions with A. viscosus is unclear. Here, we first employed 39 volunteers with root caries and 37 caries-free volunteers, and found that the abundances of C. albicans and A. viscosus were significantly increased in the individuals with root caries and showed a strong positive correlation. Their dual-species combination synergistically promoted biofilm formation and root caries in rats. The arginine biosynthesis pathway of C. albicans was significantly upregulated in dual-species biofilms and dental plaques from another 10 root caries volunteers compared with the 10 caries-free volunteers. The exogenous additio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-15T06:05:05.125Z","creation":"2025-02-19T02:49:40.155Z"},"accession":"S-EPMC9430244","cross_references":{"pubmed":["35862976"],"doi":["10.1128/spectrum.00782-22"]}}