{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(34)"],"submitter":["Lai Y"],"pubmed_abstract":["Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its deep penetration depth, showing great preclinical and clinical potential. Herein, a platinum(ii)-cyanine complex has been designed to investigate its potential as a SDT anticancer agent. It generates singlet oxygen (<sup>1</sup>O<sub>2</sub>) under ultrasound (US) irradiation or light irradiation, and exhibits US-cytotoxicity in breast cancer 4T1 cells but with negligible dark-cytotoxicity. Mechanistic investigations reveal that Pt-Cy reduces the cellular GSH and GPX4, and triggers cancer cell ferroptosis under US irradiation. The metabolomics analysis illustrates that Pt-Cy upon US treatment significantly dysregulates glutathione metabolism, and finally induces ferroptosis. <i>In vivo</i> studies further de"],"journal":["Chemical science"],"pagination":["9921-9926"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9430585"],"repository":["biostudies-literature"],"pubmed_title":["Ferroptosis promotes sonodynamic therapy: a platinum(ii)-indocyanine sonosensitizer."],"pmcid":["PMC9430585"],"pubmed_authors":["Lai Y","Ouyang A","Lu N","Zhang Q","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Ferroptosis promotes sonodynamic therapy: a platinum(ii)-indocyanine sonosensitizer.","description":"Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its deep penetration depth, showing great preclinical and clinical potential. Herein, a platinum(ii)-cyanine complex has been designed to investigate its potential as a SDT anticancer agent. It generates singlet oxygen (<sup>1</sup>O<sub>2</sub>) under ultrasound (US) irradiation or light irradiation, and exhibits US-cytotoxicity in breast cancer 4T1 cells but with negligible dark-cytotoxicity. Mechanistic investigations reveal that Pt-Cy reduces the cellular GSH and GPX4, and triggers cancer cell ferroptosis under US irradiation. The metabolomics analysis illustrates that Pt-Cy upon US treatment significantly dysregulates glutathione metabolism, and finally induces ferroptosis. <i>In vivo</i> studies further de","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-26T13:51:33.217Z","creation":"2024-11-14T20:10:43.857Z"},"accession":"S-EPMC9430585","cross_references":{"pubmed":["36128230"],"doi":["10.1039/d2sc02597c"]}}