biostudies-literatureUnknown10(4)Zhang XIn this study, we aimed to investigate the occurrence and molecular characteristics of fosfomycin-resistant <i>Enterobacteriaceae</i> isolates from pig, chicken and pigeon farms in Guangxi Province of China. A total of 200 fosfomycin-resistant strains were obtained from food animals and their surrounding environments, with the <i>fosA</i>, <i>fosA3</i>, and <i>fosA7.5</i> genes being detected in 26% (52/200), 10% (20/200), and 5% (10/200), respectively. Surprisingly, three <i>fosA7.5</i>-producing E. coli isolates were found to be concomitant with <i>fosA3</i>. Most of the <i>fosA</i>-like-gene-positive isolates were multidrug-resistant strains and consistently possessed <i>bla</i>_{CTX-M-1/CTX-M-9}, <i>floR</i>, and <i>bla</i>_TEM genes. Only <i>fosA3</i> was successfullMicrobiology spectrume0054522https://www.ebi.ac.uk/biostudies/studies/S-EPMC9431306biostudies-literatureSpread and Molecular Characteristics of <i>Enterobacteriaceae</i> Carrying <i>fosA</i>-Like Genes from Farms in China.PMC9431306Yang YQian YHuang YMa MLu YZhang XTan YSi HZhong XCheng YfalseSpread and Molecular Characteristics of <i>Enterobacteriaceae</i> Carrying <i>fosA</i>-Like Genes from Farms in China.In this study, we aimed to investigate the occurrence and molecular characteristics of fosfomycin-resistant <i>Enterobacteriaceae</i> isolates from pig, chicken and pigeon farms in Guangxi Province of China. A total of 200 fosfomycin-resistant strains were obtained from food animals and their surrounding environments, with the <i>fosA</i>, <i>fosA3</i>, and <i>fosA7.5</i> genes being detected in 26% (52/200), 10% (20/200), and 5% (10/200), respectively. Surprisingly, three <i>fosA7.5</i>-producing E. coli isolates were found to be concomitant with <i>fosA3</i>. Most of the <i>fosA</i>-like-gene-positive isolates were multidrug-resistant strains and consistently possessed <i>bla</i>_{CTX-M-1/CTX-M-9}, <i>floR</i>, and <i>bla</i>_TEM genes. Only <i>fosA3</i> was successfull2022-01-01T00:00:00Z2022 Aug2026-05-31T22:54:45.688Z2024-11-15T00:39:44.619ZS-EPMC94313063585232410.1128/spectrum.00545-22