{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liew TM"],"funding":["NIA NIH HHS","National Institute on Aging"],"pagination":["1664-1675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9433458"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(12)"],"pubmed_abstract":["<h4>Objective</h4>Subjective cognitive decline and APOE e4 allele (APOE4) are known predictors of mild cognitive impairment and dementia (mild cognitive impairment/dementia), with recent evidence showing interaction between subjective cognitive decline and APOE4 in amplifying the risk of mild cognitive impairment/dementia. However, the literature is unclear whether the interaction effect is seen across various age and sex strata. This study examined the interaction between subjective cognitive decline and APOE4-across different age and sex strata-on the risk of mild cognitive impairment/dementia.<h4>Methods</h4>This cohort study included 16,221 participants aged ⩾50 years and had normal cognition at baseline. Participants were evaluated for subjective cognitive decline and APOE4 at baselin"],"journal":["The Australian and New Zealand journal of psychiatry"],"pubmed_title":["Subjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study."],"pmcid":["PMC9433458"],"funding_grant_id":["AG016976","U01 AG016976","U24 AG072122"],"pubmed_authors":["Liew TM"],"additional_accession":[]},"is_claimable":false,"name":"Subjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study.","description":"<h4>Objective</h4>Subjective cognitive decline and APOE e4 allele (APOE4) are known predictors of mild cognitive impairment and dementia (mild cognitive impairment/dementia), with recent evidence showing interaction between subjective cognitive decline and APOE4 in amplifying the risk of mild cognitive impairment/dementia. However, the literature is unclear whether the interaction effect is seen across various age and sex strata. This study examined the interaction between subjective cognitive decline and APOE4-across different age and sex strata-on the risk of mild cognitive impairment/dementia.<h4>Methods</h4>This cohort study included 16,221 participants aged ⩾50 years and had normal cognition at baseline. Participants were evaluated for subjective cognitive decline and APOE4 at baselin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T09:44:21.391Z","creation":"2025-04-05T09:44:21.391Z"},"accession":"S-EPMC9433458","cross_references":{"pubmed":["35229693"],"doi":["10.1177/00048674221079217"]}}