biostudies-literatureLiew TMNIA NIH HHSNational Institute on Aging1664-1675https://www.ebi.ac.uk/biostudies/studies/S-EPMC9433458biostudies-literatureUnknown56(12)<h4>Objective</h4>Subjective cognitive decline and APOE e4 allele (APOE4) are known predictors of mild cognitive impairment and dementia (mild cognitive impairment/dementia), with recent evidence showing interaction between subjective cognitive decline and APOE4 in amplifying the risk of mild cognitive impairment/dementia. However, the literature is unclear whether the interaction effect is seen across various age and sex strata. This study examined the interaction between subjective cognitive decline and APOE4-across different age and sex strata-on the risk of mild cognitive impairment/dementia.<h4>Methods</h4>This cohort study included 16,221 participants aged ⩾50 years and had normal cognition at baseline. Participants were evaluated for subjective cognitive decline and APOE4 at baselinThe Australian and New Zealand journal of psychiatrySubjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study.PMC9433458AG016976U01 AG016976U24 AG072122Liew TMfalseSubjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study.<h4>Objective</h4>Subjective cognitive decline and APOE e4 allele (APOE4) are known predictors of mild cognitive impairment and dementia (mild cognitive impairment/dementia), with recent evidence showing interaction between subjective cognitive decline and APOE4 in amplifying the risk of mild cognitive impairment/dementia. However, the literature is unclear whether the interaction effect is seen across various age and sex strata. This study examined the interaction between subjective cognitive decline and APOE4-across different age and sex strata-on the risk of mild cognitive impairment/dementia.<h4>Methods</h4>This cohort study included 16,221 participants aged ⩾50 years and had normal cognition at baseline. Participants were evaluated for subjective cognitive decline and APOE4 at baselin2022-01-01T00:00:00Z2022 Dec2025-04-05T09:44:21.391Z2025-04-05T09:44:21.391ZS-EPMC94334583522969310.1177/00048674221079217