biostudies-literatureGardner OKNCATS NIH HHSNIA NIH HHSNational Institutes of HealthNational Institute on Aging2876-2886https://www.ebi.ac.uk/biostudies/studies/S-EPMC9433728biostudies-literatureUnknown31(17)Most Alzheimer's disease (AD)-associated genetic variants do not change protein coding sequence and thus likely exert their effects through regulatory mechanisms. RNA editing, the post-transcriptional modification of RNA bases, is a regulatory feature that is altered in AD patients that differs across ancestral backgrounds. Editing QTLs (edQTLs) are DNA variants that influence the level of RNA editing at a specific site. To study the relationship of DNA variants genome-wide, and particularly in AD-associated loci, with RNA editing, we performed edQTL analyses in self-reported individuals of African American (AF) or White (EU) race with corresponding global genetic ancestry averaging 82.2% African ancestry (AF) and 96.8% European global ancestry (EU) in the two groups, respectively. We usedHuman molecular geneticsGenetic architecture of RNA editing regulation in Alzheimer's disease across diverse ancestral populations.PMC9433728RF1 AG070935AG027944UL1 TR001420AG028786R01 AG070864R01 AG072547AG070935R01 AG070935R56 AG072547U01 AG032984R01 AG027944U01AG052410-01R01 AG028786AG072547U01 AG052410AG070864Gu TAdams LDStarks TDVance JMNuytemans KMartin ERByrd GSGriswold AJHaines JLWang LCuccaro MLPericak-Vance MABush WSBeecham GWHofmann NKHamilton-Nelson KLVan Booven DWhitehead PLGardner OKfalseGenetic architecture of RNA editing regulation in Alzheimer's disease across diverse ancestral populations.Most Alzheimer's disease (AD)-associated genetic variants do not change protein coding sequence and thus likely exert their effects through regulatory mechanisms. RNA editing, the post-transcriptional modification of RNA bases, is a regulatory feature that is altered in AD patients that differs across ancestral backgrounds. Editing QTLs (edQTLs) are DNA variants that influence the level of RNA editing at a specific site. To study the relationship of DNA variants genome-wide, and particularly in AD-associated loci, with RNA editing, we performed edQTL analyses in self-reported individuals of African American (AF) or White (EU) race with corresponding global genetic ancestry averaging 82.2% African ancestry (AF) and 96.8% European global ancestry (EU) in the two groups, respectively. We used2022-01-01T00:00:00Z2022 Aug2026-05-09T03:12:03.329Z2025-02-19T02:38:07.514ZS-EPMC94337283538383910.1093/hmg/ddac075