{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Li S"],"pubmed_abstract":["<h4>Background</h4>One of the most common nasal external sites in extranodal Natural Killer/T-cell lymphoma (NKTCL) is in the gastrointestinal (GI) system. Despite this, reports on gastrointestinal-Natural Killer/T-cell lymphoma (GI-NKTCL) are very few. To obtain a better understanding of this manifestation of NKTCL, we conducted a retrospective study on GI-NKTCL to analyze its clinical features, genomic changes and immune infiltration.<h4>Methods</h4>We retrospectively collected patients diagnosed with GI-NKTCL in the Sixth Affiliated Hospital of Sun Yat-sen University from 2010 to 2020. From this cohort we obtained mutation data <i>via</i> whole exome sequencing.<h4>Results</h4>Genomic analysis from 15 patients with GI-NKTCL showed that the most common driving mutations were ARID1B(14%, "],"journal":["Frontiers in oncology"],"pagination":["976762"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9434212"],"repository":["biostudies-literature"],"pubmed_title":["Integrated driver mutations profile of chinese gastrointestinal-natural killer/T-cell lymphoma."],"pmcid":["PMC9434212"],"pubmed_authors":["Liu H","Li S","Huang Y","Zhai X","Xiao J","Cao T","Lin X","Hong W","Liu T","Yu H","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Integrated driver mutations profile of chinese gastrointestinal-natural killer/T-cell lymphoma.","description":"<h4>Background</h4>One of the most common nasal external sites in extranodal Natural Killer/T-cell lymphoma (NKTCL) is in the gastrointestinal (GI) system. Despite this, reports on gastrointestinal-Natural Killer/T-cell lymphoma (GI-NKTCL) are very few. To obtain a better understanding of this manifestation of NKTCL, we conducted a retrospective study on GI-NKTCL to analyze its clinical features, genomic changes and immune infiltration.<h4>Methods</h4>We retrospectively collected patients diagnosed with GI-NKTCL in the Sixth Affiliated Hospital of Sun Yat-sen University from 2010 to 2020. From this cohort we obtained mutation data <i>via</i> whole exome sequencing.<h4>Results</h4>Genomic analysis from 15 patients with GI-NKTCL showed that the most common driving mutations were ARID1B(14%, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T07:27:33.427Z","creation":"2025-04-19T07:27:33.427Z"},"accession":"S-EPMC9434212","cross_references":{"pubmed":["36059700"],"doi":["10.3389/fonc.2022.976762"]}}