biostudies-literatureUnknown12Li S<h4>Background</h4>One of the most common nasal external sites in extranodal Natural Killer/T-cell lymphoma (NKTCL) is in the gastrointestinal (GI) system. Despite this, reports on gastrointestinal-Natural Killer/T-cell lymphoma (GI-NKTCL) are very few. To obtain a better understanding of this manifestation of NKTCL, we conducted a retrospective study on GI-NKTCL to analyze its clinical features, genomic changes and immune infiltration.<h4>Methods</h4>We retrospectively collected patients diagnosed with GI-NKTCL in the Sixth Affiliated Hospital of Sun Yat-sen University from 2010 to 2020. From this cohort we obtained mutation data <i>via</i> whole exome sequencing.<h4>Results</h4>Genomic analysis from 15 patients with GI-NKTCL showed that the most common driving mutations were ARID1B(14%, Frontiers in oncology976762https://www.ebi.ac.uk/biostudies/studies/S-EPMC9434212biostudies-literatureIntegrated driver mutations profile of chinese gastrointestinal-natural killer/T-cell lymphoma.PMC9434212Liu HLi SHuang YZhai XXiao JCao TLin XHong WLiu TYu HLi MfalseIntegrated driver mutations profile of chinese gastrointestinal-natural killer/T-cell lymphoma.<h4>Background</h4>One of the most common nasal external sites in extranodal Natural Killer/T-cell lymphoma (NKTCL) is in the gastrointestinal (GI) system. Despite this, reports on gastrointestinal-Natural Killer/T-cell lymphoma (GI-NKTCL) are very few. To obtain a better understanding of this manifestation of NKTCL, we conducted a retrospective study on GI-NKTCL to analyze its clinical features, genomic changes and immune infiltration.<h4>Methods</h4>We retrospectively collected patients diagnosed with GI-NKTCL in the Sixth Affiliated Hospital of Sun Yat-sen University from 2010 to 2020. From this cohort we obtained mutation data <i>via</i> whole exome sequencing.<h4>Results</h4>Genomic analysis from 15 patients with GI-NKTCL showed that the most common driving mutations were ARID1B(14%, 2022-01-01T00:00:00Z20222025-04-19T07:27:33.427Z2025-04-19T07:27:33.427ZS-EPMC94342123605970010.3389/fonc.2022.976762