{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Li L"],"pubmed_abstract":["<h4>Background</h4>Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM) and is one of the leading causes of blindness among DM patients. However, the molecular mechanism involving DR remains unclear.<h4>Methods</h4>A case-control study with age-, sex-, and duration-matched diabetic patients and controls was conducted, which included 15 type 2 DM (T2DM) patients with DR and 15 T2DM patients without DR. Shotgun sequencing and non-targeted metabolomic profiling analyses of fecal samples were performed, and comprehensive bioinformatics analyses were conducted.<h4>Results</h4>Using metagenomic analyses, we identified 293,460 unique genes in the non-DR group, while that in the DR group was 283,235, and the number of overlapping genes was 1,237,914. Regarding"],"journal":["Frontiers in immunology"],"pagination":["943325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9434375"],"repository":["biostudies-literature"],"pubmed_title":["Metagenomic shotgun sequencing and metabolomic profiling identify specific human gut microbiota associated with diabetic retinopathy in patients with type 2 diabetes."],"pmcid":["PMC9434375"],"pubmed_authors":["Yang X","Li C","Chen K","Liu L","Yang K","Zhang H","Li L","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"Metagenomic shotgun sequencing and metabolomic profiling identify specific human gut microbiota associated with diabetic retinopathy in patients with type 2 diabetes.","description":"<h4>Background</h4>Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM) and is one of the leading causes of blindness among DM patients. However, the molecular mechanism involving DR remains unclear.<h4>Methods</h4>A case-control study with age-, sex-, and duration-matched diabetic patients and controls was conducted, which included 15 type 2 DM (T2DM) patients with DR and 15 T2DM patients without DR. Shotgun sequencing and non-targeted metabolomic profiling analyses of fecal samples were performed, and comprehensive bioinformatics analyses were conducted.<h4>Results</h4>Using metagenomic analyses, we identified 293,460 unique genes in the non-DR group, while that in the DR group was 283,235, and the number of overlapping genes was 1,237,914. Regarding","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T16:04:53.421Z","creation":"2025-02-19T01:27:10.042Z"},"accession":"S-EPMC9434375","cross_references":{"pubmed":["36059453"],"doi":["10.3389/fimmu.2022.943325"]}}