biostudies-literatureUnknown48(5)Berkovitch L<h4>Background and hypothesis</h4>Motivation deficit is a hallmark of schizophrenia that has a strong impact on their daily life. An alteration of reward processing has been repeatedly highlighted in schizophrenia, but to what extent it involves a deficient amplification of reward representation through conscious processing remains unclear. Indeed, patients with schizophrenia exhibit a disruption of conscious processing, whereas unconscious processing appears to be largely preserved.<h4>Study design</h4>To further explore the nature of motivational deficit in schizophrenia and the implication of consciousness disruption in this symptom, we used a masking paradigm testing motivation both under conscious and unconscious conditions in patients with schizophrenia (n = 31) and healthy controls Schizophrenia bulletin1094-1103https://www.ebi.ac.uk/biostudies/studies/S-EPMC9434445biostudies-literaturePreserved Unconscious Processing in Schizophrenia: The Case of Motivation.PMC9434445Plaze MGauthier CGaillard RSmadja SBeaucamps HPessiglione MBerkovitch LAttali DVinckier FAbdel-Ahad PfalsePreserved Unconscious Processing in Schizophrenia: The Case of Motivation.<h4>Background and hypothesis</h4>Motivation deficit is a hallmark of schizophrenia that has a strong impact on their daily life. An alteration of reward processing has been repeatedly highlighted in schizophrenia, but to what extent it involves a deficient amplification of reward representation through conscious processing remains unclear. Indeed, patients with schizophrenia exhibit a disruption of conscious processing, whereas unconscious processing appears to be largely preserved.<h4>Study design</h4>To further explore the nature of motivational deficit in schizophrenia and the implication of consciousness disruption in this symptom, we used a masking paradigm testing motivation both under conscious and unconscious conditions in patients with schizophrenia (n = 31) and healthy controls 2022-01-01T00:00:00Z2022 Sep2025-04-04T18:42:32.255Z2025-04-04T18:42:32.255ZS-EPMC94344453575151610.1093/schbul/sbac076