{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sano K"],"funding":["NIAID NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","U.S. Department of Health & Human Services | NIH | National Cancer Institute","NCI NIH HHS"],"pagination":["5135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9435409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19."],"journal":["Nature communications"],"pubmed_title":["SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals."],"pmcid":["PMC9435409"],"funding_grant_id":["75N93019C00051","75N91019D00024"],"pubmed_authors":["Raskin A","Bermudez-Gonzalez MC","Mulder LCF","Simon V","Oostenink A","Salimbangon ABT","Wajnberg A","Amoako AA","Cai G","Singh G","Krammer F","Beach KF","Saksena M","Cognigni C","Floda D","Russo KT","Lyttle N","Sominsky LA","Gleason C","Andre D","Mendez W","Bhavsar D","Sano K","Carreno JM","Kawabata H","Kleiner G","Rooker A","Srivastava K","PARIS Study Group","Tcheou J"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals.","description":"Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-06-20T03:23:49.698Z","creation":"2025-02-19T04:03:00.528Z"},"accession":"S-EPMC9435409","cross_references":{"pubmed":["36050304"],"doi":["10.1038/s41467-022-32389-8"]}}