biostudies-literatureHingorani SNIH National Institute of Neurological Disorders and StrokeNIH National Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSNINDS NIH HHS1129-1138https://www.ebi.ac.uk/biostudies/studies/S-EPMC9435989biostudies-literatureUnknown17(8)<h4>Background and objectives</h4>Extremely low gestational age neonates born <28 weeks gestation are at risk for chronic disease. We sought to describe the prevalence of kidney outcomes by gestational age and determine risk factors for their development.<h4>Design, setting, participants, & measurements</h4>The Recombinant Erythropoietin for Protection of Infant Renal Disease (REPAIReD) study examined kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo NeuroProtection Trial (PENUT) study. Kidney function, urine albumin, and BP were measured at 2-year (24±2 months) corrected gestational age. We compared outcomes across gestational age categories and evaluated associations between kidney-related outcomes and neonatal and maternal characteristics. The primaryClinical journal of the American Society of Nephrology : CJASNPrevalence and Risk Factors for Kidney Disease and Elevated BP in 2-Year-Old Children Born Extremely Premature.PMC9435989U01 NS077953R01DK103608R01 DK103608U01 NS077955Talele NBazacliu CValdez RCKuan EDaly RPatel PAhmad KAThomas VMBTalbot MBarnhart LPENUT Primary Investigators and coauthorsRau CWright JBeauman SGalvis EMHanson MSchau MLa Gamma EFJuul SEMora AFPerez JESchmicker RKaletka BGilmore MMFisher MO'Shea TMDrake TOsborne MPPenny SPENUT Trial ConsortiumNefcy CMason MMcGrath KDavern BGeorgieff MLee KSchaefer SHeagerty PJMartin CRSaurabhkumar PCole LYoder BBird KGeorge TElhassan NKase JSKonodi MALacy CBLewis KWWadhawan RWegner RECheck JKohlleppel KBoles TMayock DEdeRegnier RAParkinson CAskenazi DWassenaar JLanier KHingorani SO'Shea MLampland ASikes NHedrick PPearson DDrummond MOsterholm ENorthington FNason JO'Reilly DGinder ARao RGoldstein SWyatt ABrophy PBurnett JClarke MGuy ARussow AObregon EMulrooney NBaserga MFeltner JBKuban KLowe JRichards TBombino SEricksen JDowney LCKhan JYOhls RKReich BCourtney SECurry KNikirk SLoy EMartinez DLong CWorwa CRichter TBendel-Stenzel EGonzales SWarden KWalden DSilvia AFlynn VPorta NZiyeh TVijayamadhavan VKFahim NEsposito IWeiss MHarrison HHartman PTVASrinivasan NLoertscher MBallard RDiaz-Barbosa MHauge SGiblin CRobinson TMcConnell JFrantz IDClopp BWidness JKhan JLaGamma EFBell SKathen CMulkey SOtt DBrown TfalsePrevalence and Risk Factors for Kidney Disease and Elevated BP in 2-Year-Old Children Born Extremely Premature.<h4>Background and objectives</h4>Extremely low gestational age neonates born <28 weeks gestation are at risk for chronic disease. We sought to describe the prevalence of kidney outcomes by gestational age and determine risk factors for their development.<h4>Design, setting, participants, & measurements</h4>The Recombinant Erythropoietin for Protection of Infant Renal Disease (REPAIReD) study examined kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo NeuroProtection Trial (PENUT) study. Kidney function, urine albumin, and BP were measured at 2-year (24±2 months) corrected gestational age. We compared outcomes across gestational age categories and evaluated associations between kidney-related outcomes and neonatal and maternal characteristics. The primary2022-01-01T00:00:00Z2022 Aug2026-05-28T01:56:33.164Z2025-04-04T20:28:49.461ZS-EPMC94359893585372810.2215/CJN.1501112110.2215/cjn.15011121