{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding H"],"funding":["National Natural Science Foundation of China"],"pagination":["2459-2472"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9436683"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(17)"],"pubmed_abstract":["<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc-bing domains that catalyze ubiquitin to substrate proteins. The RBR family of E3 ubiquitin ligases has been reported in various human malignancies, but the roles of RBR E3 ubiquitin ligases in LUAD remain unclear.<h4>Methods</h4>By using TCGA and Kaplan-Meier plotter databases, we examined the expression and prognostic value of RBR E3 ubiquitin ligases. cBioPortal was used to analyze genetic mutations. The STRING database was used to build a protein interactive network. GO, KEGG, and GSEA were performed to investigate the potential biological functions of RBR E3 ubiquiti"],"journal":["Thoracic cancer"],"pubmed_title":["Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma."],"pmcid":["PMC9436683"],"funding_grant_id":["81873417"],"pubmed_authors":["Ding H","Yang J","Li C","Ding C","Xu C","Li Y","Yang Y","Chen Z","Cui Y","Wang Y","Xia D","Zhao J","Chen T"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma.","description":"<h4>Background</h4>Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc-bing domains that catalyze ubiquitin to substrate proteins. The RBR family of E3 ubiquitin ligases has been reported in various human malignancies, but the roles of RBR E3 ubiquitin ligases in LUAD remain unclear.<h4>Methods</h4>By using TCGA and Kaplan-Meier plotter databases, we examined the expression and prognostic value of RBR E3 ubiquitin ligases. cBioPortal was used to analyze genetic mutations. The STRING database was used to build a protein interactive network. GO, KEGG, and GSEA were performed to investigate the potential biological functions of RBR E3 ubiquiti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-28T04:23:13.342Z","creation":"2025-04-07T02:19:03.407Z"},"accession":"S-EPMC9436683","cross_references":{"pubmed":["35820682"],"doi":["10.1111/1759-7714.14577"]}}