{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bein KJ"],"funding":["National Institute of Environmental Health Sciences","NIA NIH HHS","NIEHS NIH HHS","National Institute for Occupational Safety and Health","NIOSH CDC HHS","National Institute on Aging"],"pubmed_abstract":["Epidemiological and toxicological studies continue to demonstrate correlative and causal relationships between exposure to traffic-related air pollution and various metrics of adverse pulmonary, cardiovascular, and neurological health effects. The key challenge for in vivo studies is replicating real-world, near-roadway exposure dynamics in laboratory animal models that mimic true human exposures. The advantage of animal models is the accelerated time scales to show statistically significant physiological and/or behavioral response. This work describes a novel exposure facility adjacent to a major freeway tunnel system that provides a platform for real-time chronic exposure studies. The primary conclusion is that particulate matter (PM) concentrations at this facility are routinely well be"],"journal":["Environmental science & technology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9437142"],"repository":["biostudies-literature"],"pubmed_title":["Emulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System."],"pmcid":["PMC9437142"],"funding_grant_id":["R21ES025570","P30ES023513","R01ES026670","R21 ES026515","RF1 AG074709","RF1AG074709","P30 ES023513","P30AG010129","P30 AG010129","U54 OH007550","R21 ES025570","R21ES026515"],"pubmed_authors":["Wexler AS","Wallis CD","Lein PJ","Silverman JL","Bein KJ"],"additional_accession":[]},"is_claimable":false,"name":"Emulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System.","description":"Epidemiological and toxicological studies continue to demonstrate correlative and causal relationships between exposure to traffic-related air pollution and various metrics of adverse pulmonary, cardiovascular, and neurological health effects. The key challenge for in vivo studies is replicating real-world, near-roadway exposure dynamics in laboratory animal models that mimic true human exposures. The advantage of animal models is the accelerated time scales to show statistically significant physiological and/or behavioral response. This work describes a novel exposure facility adjacent to a major freeway tunnel system that provides a platform for real-time chronic exposure studies. The primary conclusion is that particulate matter (PM) concentrations at this facility are routinely well be","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T22:54:29.741Z","creation":"2025-04-04T22:54:29.741Z"},"accession":"S-EPMC9437142","cross_references":{"pubmed":["35235290"],"doi":["10.1021/acs.est.1c07047"]}}