biostudies-literatureUnknownBein KJNational Institute of Environmental Health SciencesNIA NIH HHSNIEHS NIH HHSNational Institute for Occupational Safety and HealthNIOSH CDC HHSNational Institute on AgingEpidemiological and toxicological studies continue to demonstrate correlative and causal relationships between exposure to traffic-related air pollution and various metrics of adverse pulmonary, cardiovascular, and neurological health effects. The key challenge for in vivo studies is replicating real-world, near-roadway exposure dynamics in laboratory animal models that mimic true human exposures. The advantage of animal models is the accelerated time scales to show statistically significant physiological and/or behavioral response. This work describes a novel exposure facility adjacent to a major freeway tunnel system that provides a platform for real-time chronic exposure studies. The primary conclusion is that particulate matter (PM) concentrations at this facility are routinely well beEnvironmental science & technologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9437142biostudies-literatureEmulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System.PMC9437142R21ES025570P30ES023513R01ES026670R21 ES026515RF1 AG074709RF1AG074709P30 ES023513P30AG010129P30 AG010129U54 OH007550R21 ES025570R21ES026515Wexler ASWallis CDLein PJSilverman JLBein KJfalseEmulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System.Epidemiological and toxicological studies continue to demonstrate correlative and causal relationships between exposure to traffic-related air pollution and various metrics of adverse pulmonary, cardiovascular, and neurological health effects. The key challenge for in vivo studies is replicating real-world, near-roadway exposure dynamics in laboratory animal models that mimic true human exposures. The advantage of animal models is the accelerated time scales to show statistically significant physiological and/or behavioral response. This work describes a novel exposure facility adjacent to a major freeway tunnel system that provides a platform for real-time chronic exposure studies. The primary conclusion is that particulate matter (PM) concentrations at this facility are routinely well be2022-01-01T00:00:00Z2022 Mar2025-04-04T22:54:29.741Z2025-04-04T22:54:29.741ZS-EPMC94371423523529010.1021/acs.est.1c07047