{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["50(8)"],"submitter":["Xie X"],"pubmed_abstract":["<h4>Objective</h4>To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D).<h4>Methods</h4>In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma glucose (FPG) values. IRAK-M and metabolic parameters, including fasting insulin (FINS), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), and thioredoxin-interacting protein (TXNIP), were evaluated. The area under the receiver operating characteristic curve of IRAK-M and TXNIP for prediabetes and T2D was determined.<h4>Results</h4>IRAK-M decreased significantly with increasing FPG levels. IRAK-M was negatively correlated with TXNIP, FPG, FINS, HbA1c, and"],"journal":["The Journal of international medical research"],"pagination":["3000605221111275"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9437484"],"repository":["biostudies-literature"],"pubmed_title":["Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study."],"pmcid":["PMC9437484"],"pubmed_authors":["Liu H","Xie X","Qiang D","Zhang L","Li L","Bai G"],"additional_accession":[]},"is_claimable":false,"name":"Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.","description":"<h4>Objective</h4>To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D).<h4>Methods</h4>In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma glucose (FPG) values. IRAK-M and metabolic parameters, including fasting insulin (FINS), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), and thioredoxin-interacting protein (TXNIP), were evaluated. The area under the receiver operating characteristic curve of IRAK-M and TXNIP for prediabetes and T2D was determined.<h4>Results</h4>IRAK-M decreased significantly with increasing FPG levels. IRAK-M was negatively correlated with TXNIP, FPG, FINS, HbA1c, and","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-05-29T20:01:37.75Z","creation":"2024-11-06T15:55:25.207Z"},"accession":"S-EPMC9437484","cross_references":{"pubmed":["36039603"],"doi":["10.1177/03000605221111275"]}}