biostudies-literatureUnknown50(8)Xie X<h4>Objective</h4>To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D).<h4>Methods</h4>In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma glucose (FPG) values. IRAK-M and metabolic parameters, including fasting insulin (FINS), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), and thioredoxin-interacting protein (TXNIP), were evaluated. The area under the receiver operating characteristic curve of IRAK-M and TXNIP for prediabetes and T2D was determined.<h4>Results</h4>IRAK-M decreased significantly with increasing FPG levels. IRAK-M was negatively correlated with TXNIP, FPG, FINS, HbA1c, andThe Journal of international medical research3000605221111275https://www.ebi.ac.uk/biostudies/studies/S-EPMC9437484biostudies-literatureChanges in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.PMC9437484Liu HXie XQiang DZhang LLi LBai GfalseChanges in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.<h4>Objective</h4>To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D).<h4>Methods</h4>In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma glucose (FPG) values. IRAK-M and metabolic parameters, including fasting insulin (FINS), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), and thioredoxin-interacting protein (TXNIP), were evaluated. The area under the receiver operating characteristic curve of IRAK-M and TXNIP for prediabetes and T2D was determined.<h4>Results</h4>IRAK-M decreased significantly with increasing FPG levels. IRAK-M was negatively correlated with TXNIP, FPG, FINS, HbA1c, and2022-01-01T00:00:00Z2022 Aug2025-05-29T20:01:37.75Z2024-11-06T15:55:25.207ZS-EPMC94374843603960310.1177/03000605221111275