biostudies-literatureDulai PSNIDDK NIH HHS1288-1295https://www.ebi.ac.uk/biostudies/studies/S-EPMC9437635biostudies-literatureUnknown117(8)<h4>Introduction</h4>Limited guidance exists for the postdischarge care of patients with ulcerative colitis hospitalized for moderate-severe flares.<h4>Methods</h4>RAND methodology was used to establish appropriateness of inpatient and postdischarge steroid dosing, discharge criteria, follow-up, and postdischarge biologic or small molecule initiation. A literature review informed on the panel's voting, which occurred anonymously during 2 rounds before and after a moderated virtual session.<h4>Results</h4>Methylprednisolone 40-60 mg intravenous every 24 hours or hydrocortisone 100 mg intravenous 3 times daily is appropriate for inpatient management, with methylprednisolone 40 mg being appropriate if intolerant of higher doses. It is appropriate to discharge patients once rectal bleeding hasThe American journal of gastroenterologyRecommendations on the Appropriate Management of Steroids and Discharge Planning During and After Hospital Admission for Moderate-Severe Ulcerative Colitis: Results of a RAND Appropriateness Panel.PMC9437635U34 DK126626Rai VTuskey ADamas OMSofia MAHanauer SBSauk JSAfzali ADeepak PYarur AJCross RKKochhar GSRaffals LELevy ANDulai PSSiegel CAHudesman DLukin DAnanthakrishnan ANfalseRecommendations on the Appropriate Management of Steroids and Discharge Planning During and After Hospital Admission for Moderate-Severe Ulcerative Colitis: Results of a RAND Appropriateness Panel.<h4>Introduction</h4>Limited guidance exists for the postdischarge care of patients with ulcerative colitis hospitalized for moderate-severe flares.<h4>Methods</h4>RAND methodology was used to establish appropriateness of inpatient and postdischarge steroid dosing, discharge criteria, follow-up, and postdischarge biologic or small molecule initiation. A literature review informed on the panel's voting, which occurred anonymously during 2 rounds before and after a moderated virtual session.<h4>Results</h4>Methylprednisolone 40-60 mg intravenous every 24 hours or hydrocortisone 100 mg intravenous 3 times daily is appropriate for inpatient management, with methylprednisolone 40 mg being appropriate if intolerant of higher doses. It is appropriate to discharge patients once rectal bleeding has2022-01-01T00:00:00Z2022 Aug2025-04-04T20:07:15.616Z2025-04-04T20:07:15.616ZS-EPMC94376353541679910.14309/ajg.0000000000001775