{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Violan C"],"funding":["Regional Ministry of Health of the Generalitat de Catalunya"],"pagination":["721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9439943"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months.<h4>Methods</h4>We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The model"],"journal":["BMC infectious diseases"],"pubmed_title":["Kinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study."],"pmcid":["PMC9439943"],"funding_grant_id":["Call COVID19-PoC SLT16_04"],"pubmed_authors":["Pujol A","de Osaba JBM","Caceres EMM","Iglesias IA","Bonet JM","Moyano EJ","Manresa-Dominguez JM","Palma AN","Lamonja-Vicente N","Chacon C","Segura EG","Garcia-Sierra R","Ortega EO","Monteagudo M","Rivas GF","Violan C","Moreno-Millan N","Perich EB","Kielpilanen A","Costa MA","Cintas VS","Lombarte OB","Gabriel EM","Martinez AL","Lozano FR","Prat N","Clotet B","Dacosta-Aguayo R","Gonzalez MJA","ProHEpiC-19 study","Carabelli J","Dolade M","Roca AO","Toran-Monserrat P","Armestar F","Ramos-Roure F","Rodriguez MP","Prado JG","Garcia MS","Ouchi D","Carrasco-Ribelles LA","Roso-Llorach A","Roldan EM","Varas EL","Aguilar JM","Blanco I","Duran AV","Caballero RP","Espinoza MS","de San Jose MM","Rosa LB","Trigo LT","Boigues-Pons M","Palacios-Fernandez C","Cano CP","Pradells AD","Camacho AP","Devesa MB","Graells ED","Poderos RP","Quirant B","Montero-Alia P","Abos SM","Lopez MAM"],"additional_accession":[]},"is_claimable":false,"name":"Kinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study.","description":"<h4>Background</h4>Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months.<h4>Methods</h4>We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The model","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-07-14T15:56:52.19Z","creation":"2025-02-19T04:03:10.571Z"},"accession":"S-EPMC9439943","cross_references":{"pubmed":["36057544"],"doi":["10.1186/s12879-022-07696-6"]}}