biostudies-literatureViolan CRegional Ministry of Health of the Generalitat de Catalunya721https://www.ebi.ac.uk/biostudies/studies/S-EPMC9439943biostudies-literatureUnknown22(1)<h4>Background</h4>Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months.<h4>Methods</h4>We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The modelBMC infectious diseasesKinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study.PMC9439943Call COVID19-PoC SLT16_04Pujol Ade Osaba JBMCaceres EMMIglesias IABonet JMMoyano EJManresa-Dominguez JMPalma ANLamonja-Vicente NChacon CSegura EGGarcia-Sierra ROrtega EOMonteagudo MRivas GFViolan CMoreno-Millan NPerich EBKielpilanen ACosta MACintas VSLombarte OBGabriel EMMartinez ALLozano FRPrat NClotet BDacosta-Aguayo RGonzalez MJAProHEpiC-19 studyCarabelli JDolade MRoca AOToran-Monserrat PArmestar FRamos-Roure FRodriguez MPPrado JGGarcia MSOuchi DCarrasco-Ribelles LARoso-Llorach ARoldan EMVaras ELAguilar JMBlanco IDuran AVCaballero RPEspinoza MSde San Jose MMRosa LBTrigo LTBoigues-Pons MPalacios-Fernandez CCano CPPradells ADCamacho APDevesa MBGraells EDPoderos RPQuirant BMontero-Alia PAbos SMLopez MAMfalseKinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study.<h4>Background</h4>Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months.<h4>Methods</h4>We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The model2022-01-01T00:00:00Z2022 Sep2026-07-14T15:56:52.19Z2025-02-19T04:03:10.571ZS-EPMC94399433605754410.1186/s12879-022-07696-6