biostudies-literatureKhurshid SU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)American Heart Association (American Heart Association, Inc.)131https://www.ebi.ac.uk/biostudies/studies/S-EPMC9440134biostudies-literatureUnknown5(1)Physical activity is regarded as favorable to health but effects across the spectrum of human disease are poorly quantified. In contrast to self-reported measures, wearable accelerometers can provide more precise and reproducible activity quantification. Using wrist-worn accelerometry data from the UK Biobank prospective cohort study, we test associations between moderate-to-vigorous physical activity (MVPA) - both total MVPA minutes and whether MVPA is above a guideline-based threshold of ≥150 min/week-and incidence of 697 diseases using Cox proportional hazards models adjusted for age, sex, body mass index, smoking, Townsend Deprivation Index, educational attainment, diet quality, alcohol use, blood pressure, anti-hypertensive use. We correct for multiplicity at a false discovery rate ofNPJ digital medicineWearable accelerometer-derived physical activity and incident disease.PMC9440134R01HL139731R01HL141434R01HL092577K24HL10578018SFRN34250007T32HL00760418SFRN341100821RO1HL0925771R01AG066914R01AG0660102U54HL120163Pirruccello JPVenn RAKhurshid SWeng LCEllinor PTAl-Alusi MALubitz SANauffal VBenjamin EJfalseWearable accelerometer-derived physical activity and incident disease.Physical activity is regarded as favorable to health but effects across the spectrum of human disease are poorly quantified. In contrast to self-reported measures, wearable accelerometers can provide more precise and reproducible activity quantification. Using wrist-worn accelerometry data from the UK Biobank prospective cohort study, we test associations between moderate-to-vigorous physical activity (MVPA) - both total MVPA minutes and whether MVPA is above a guideline-based threshold of ≥150 min/week-and incidence of 697 diseases using Cox proportional hazards models adjusted for age, sex, body mass index, smoking, Townsend Deprivation Index, educational attainment, diet quality, alcohol use, blood pressure, anti-hypertensive use. We correct for multiplicity at a false discovery rate of2022-01-01T00:00:00Z2022 Sep2025-04-18T20:53:37.899Z2025-04-07T08:58:32.315ZS-EPMC94401343605619010.1038/s41746-022-00676-9