{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(9)"],"submitter":["Kim H"],"pubmed_abstract":["Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics regulated by mitochondria-localized nuclear TFs are yet to be fully characterized. Here, we identify STAT6 as a mitochondrial protein that is localized in the outer membrane of mitochondria (OMM). STAT6 in OMM inhibits mitochondrial fusion by blocking MFN2 dimerization. This implies that STAT6 has a critical role in mitochondrial dynamics. Moreover, mitochondrial accumulation of STAT6 in response to hypoxic conditions reveals that STAT6 is a regulator of mitochondrial processes including fusion/fission mechanisms."],"journal":["iScience"],"pagination":["104923"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9440285"],"repository":["biostudies-literature"],"pubmed_title":["STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization."],"pmcid":["PMC9440285"],"pubmed_authors":["Kim H","Park SJ","Jou I"],"additional_accession":[]},"is_claimable":false,"name":"STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization.","description":"Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics regulated by mitochondria-localized nuclear TFs are yet to be fully characterized. Here, we identify STAT6 as a mitochondrial protein that is localized in the outer membrane of mitochondria (OMM). STAT6 in OMM inhibits mitochondrial fusion by blocking MFN2 dimerization. This implies that STAT6 has a critical role in mitochondrial dynamics. Moreover, mitochondrial accumulation of STAT6 in response to hypoxic conditions reveals that STAT6 is a regulator of mitochondrial processes including fusion/fission mechanisms.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T13:33:36.475Z","creation":"2025-02-19T04:02:36.461Z"},"accession":"S-EPMC9440285","cross_references":{"pubmed":["36065189"],"doi":["10.1016/j.isci.2022.104923"]}}