{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ogura Y"],"funding":["National Heart, Lung, and Blood Institute","Ministry of Education, Culture, Sports, Science and Technology","University of Tsukuba","National Institutes of Health"],"pagination":["102335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9440431"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["298(9)"],"pubmed_abstract":["Disordered expression and distribution of plasma membrane proteins at the cell surface leads to diverse malignant phenotypes in tumors, including cell invasion. The ubiquitin-specific protease TRE17/USP6, an oncogene identified in Ewing sarcoma, is highly expressed in several cancers and locally aggressive tumor-like lesions. We have previously demonstrated that TRE17 regulates the trafficking of plasma membrane proteins that enter cells via clathrin-independent endocytosis (CIE); TRE17 prevents CIE cargo proteins from being targeted to lysosomes for degradation by deubiquitylating them. However, functional insights into the effects of TRE17-mediated CIE cargo trafficking on cell invasion remain unknown. Here, we show that increased expression of TRE17 enhances invasiveness of the human sa"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking."],"pmcid":["PMC9440431"],"funding_grant_id":["HT-1080","21K06146","17K07327","22K06199","18H02601","CD147","19K06653"],"pubmed_authors":["Ogura Y","Kawaguchi A","Kanaho Y","Ohbayashi N","Funakoshi Y"],"additional_accession":[]},"is_claimable":false,"name":"Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking.","description":"Disordered expression and distribution of plasma membrane proteins at the cell surface leads to diverse malignant phenotypes in tumors, including cell invasion. The ubiquitin-specific protease TRE17/USP6, an oncogene identified in Ewing sarcoma, is highly expressed in several cancers and locally aggressive tumor-like lesions. We have previously demonstrated that TRE17 regulates the trafficking of plasma membrane proteins that enter cells via clathrin-independent endocytosis (CIE); TRE17 prevents CIE cargo proteins from being targeted to lysosomes for degradation by deubiquitylating them. However, functional insights into the effects of TRE17-mediated CIE cargo trafficking on cell invasion remain unknown. Here, we show that increased expression of TRE17 enhances invasiveness of the human sa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-20T00:42:54.937Z","creation":"2025-04-20T00:42:54.937Z"},"accession":"S-EPMC9440431","cross_references":{"pubmed":["35926707"],"doi":["10.1016/j.jbc.2022.102335"]}}