{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Yamamoto T"],"pubmed_abstract":["Paraspeckles are nuclear bodies scaffolded by RNP complexes of NEAT1_2 RNA transcripts and multiple RNA-binding proteins. The assembly of paraspeckles is coupled with the transcription of NEAT1_2. Paraspeckles form the core-shell structure, where the two terminal regions of NEAT1_2 RNP complexes compose the shell of the paraspeckle and the middle regions of these complexes compose the core. We here construct a theoretical model of paraspeckles by taking into account the transcription of NEAT1_2 in an extension of the theory of block copolymer micelles. This theory predicts that the core-shell structure of a paraspeckle is assembled by the association of the middle region of NEAT1_2 RNP complexes due to the multivalent interactions between RBPs bound to these regions and by the relative aff"],"journal":["Frontiers in molecular biosciences"],"pagination":["925058"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9441768"],"repository":["biostudies-literature"],"pubmed_title":["Triblock copolymer micelle model of spherical paraspeckles."],"pmcid":["PMC9441768"],"pubmed_authors":["Yamamoto T","Hirose T","Yamazaki T"],"additional_accession":[]},"is_claimable":false,"name":"Triblock copolymer micelle model of spherical paraspeckles.","description":"Paraspeckles are nuclear bodies scaffolded by RNP complexes of NEAT1_2 RNA transcripts and multiple RNA-binding proteins. The assembly of paraspeckles is coupled with the transcription of NEAT1_2. Paraspeckles form the core-shell structure, where the two terminal regions of NEAT1_2 RNP complexes compose the shell of the paraspeckle and the middle regions of these complexes compose the core. We here construct a theoretical model of paraspeckles by taking into account the transcription of NEAT1_2 in an extension of the theory of block copolymer micelles. This theory predicts that the core-shell structure of a paraspeckle is assembled by the association of the middle region of NEAT1_2 RNP complexes due to the multivalent interactions between RBPs bound to these regions and by the relative aff","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T12:26:08.167Z","creation":"2025-02-18T23:48:21.646Z"},"accession":"S-EPMC9441768","cross_references":{"pubmed":["36072433"],"doi":["10.3389/fmolb.2022.925058"]}}