{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Khare K"],"funding":["Bill and Melinda Gates Foundation","AIDS Healthcare Foundation"],"pubmed_abstract":["During an infectious disease progression, it is crucial to understand the cellular heterogeneity underlying the differential immune response landscape that will augment the precise information of the disease severity modulators, leading to differential clinical outcome. Patients with COVID-19 display a complex yet regulated immune profile with a heterogeneous array of clinical manifestation that delineates disease severity sub-phenotypes and worst clinical outcomes. Therefore, it is necessary to elucidate/understand/enumerate the role of cellular heterogeneity during COVID-19 disease to understand the underlying immunological mechanisms regulating the disease severity. This article aims to comprehend the current findings regarding dysregulation and impairment of immune response in COVID-19"],"journal":["Frontiers in immunology"],"pagination":["973070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9441806"],"repository":["biostudies-literature"],"pubmed_title":["Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key."],"pmcid":["PMC9441806"],"pubmed_authors":["Khare K","Pandey R"],"additional_accession":[]},"is_claimable":false,"name":"Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key.","description":"During an infectious disease progression, it is crucial to understand the cellular heterogeneity underlying the differential immune response landscape that will augment the precise information of the disease severity modulators, leading to differential clinical outcome. Patients with COVID-19 display a complex yet regulated immune profile with a heterogeneous array of clinical manifestation that delineates disease severity sub-phenotypes and worst clinical outcomes. Therefore, it is necessary to elucidate/understand/enumerate the role of cellular heterogeneity during COVID-19 disease to understand the underlying immunological mechanisms regulating the disease severity. This article aims to comprehend the current findings regarding dysregulation and impairment of immune response in COVID-19","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T21:08:40.542Z","creation":"2024-11-08T20:00:58.145Z"},"accession":"S-EPMC9441806","cross_references":{"pubmed":["36072602"],"doi":["10.3389/fimmu.2022.973070"]}}